Layered terbium hydroxides for simultaneous drug delivery and imaging

Margarita Strimaite; Clarissa L.G. Harman; Huan Duan; Yuwei Wang; Gemma Louise Davies; Gareth R. Williams

doi:10.1039/d1dt01251g

Layered terbium hydroxides for simultaneous drug delivery and imaging

Margarita Strimaite, Clarissa L.G. Harman, Huan Duan, Yuwei Wang, Gemma Louise Davies, Gareth R. Williams^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

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Abstract

Layered rare-earth hydroxides have begun to gather increasing attention as potential theranostic platforms owing to their extensive intercalation chemistry combined with magnetic and fluorescent properties. In this work, the potential of layered terbium hydroxide (LTbH) as a platform for simultaneous drug delivery and fluorescence imaging was evaluated. LTbH-Cl ([Tb₂(OH)₅]Cl·yH₂O) was loaded with three nonsteroidal anti-inflammatory drugs (diclofenac, ibuprofen, and naproxen)viaion-exchange. Drug release studies in phosphate buffered saline (pH = 7.4) revealed all three formulations release their drug cargo rapidly over the course of approximately 5 hours. In addition, solid state fluorescence studies indicated that fluorescence intensity is strongly dependent on the identity of the guest anion. It was postulated that this feature may be used to track the extent of drug release from the formulation, which was subsequently successfully demonstrated for the ibuprofen loaded LTbH. Overall, LTbH exhibits good biocompatibility, high drug loading, and a strong, guest-dependent fluorescence signal, all of which are desirable qualities for theranostic applications.

Original language	English
Pages (from-to)	10275-10290
Number of pages	16
Journal	Dalton Transactions
Volume	50
Issue number	29
Early online date	6 Jul 2021
DOIs	https://doi.org/10.1039/d1dt01251g
Publication status	Published - 7 Aug 2021

Bibliographical note

Funding Information:
MS and CLGH kindly thank the Engineering and Physical Sciences Research Council (EPSRC) for PhD funding through the Centre for Doctoral Training in Advanced Therapeutics & Nanomedicines (EP/L01646X/1). YW would like to thank the China Scholarship Council for providing a scholarship to study at UCL.

Publisher Copyright:
© The Royal Society of Chemistry 2021.

ASJC Scopus subject areas

Inorganic Chemistry

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StrimaiteM2021LayeredFinal published version, 7.11 MBLicence: Creative Commons: Attribution (CC BY)

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title = "Layered terbium hydroxides for simultaneous drug delivery and imaging",

abstract = "Layered rare-earth hydroxides have begun to gather increasing attention as potential theranostic platforms owing to their extensive intercalation chemistry combined with magnetic and fluorescent properties. In this work, the potential of layered terbium hydroxide (LTbH) as a platform for simultaneous drug delivery and fluorescence imaging was evaluated. LTbH-Cl ([Tb2(OH)5]Cl·yH2O) was loaded with three nonsteroidal anti-inflammatory drugs (diclofenac, ibuprofen, and naproxen)viaion-exchange. Drug release studies in phosphate buffered saline (pH = 7.4) revealed all three formulations release their drug cargo rapidly over the course of approximately 5 hours. In addition, solid state fluorescence studies indicated that fluorescence intensity is strongly dependent on the identity of the guest anion. It was postulated that this feature may be used to track the extent of drug release from the formulation, which was subsequently successfully demonstrated for the ibuprofen loaded LTbH. Overall, LTbH exhibits good biocompatibility, high drug loading, and a strong, guest-dependent fluorescence signal, all of which are desirable qualities for theranostic applications.",

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AU - Davies, Gemma Louise

AU - Williams, Gareth R.

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N2 - Layered rare-earth hydroxides have begun to gather increasing attention as potential theranostic platforms owing to their extensive intercalation chemistry combined with magnetic and fluorescent properties. In this work, the potential of layered terbium hydroxide (LTbH) as a platform for simultaneous drug delivery and fluorescence imaging was evaluated. LTbH-Cl ([Tb2(OH)5]Cl·yH2O) was loaded with three nonsteroidal anti-inflammatory drugs (diclofenac, ibuprofen, and naproxen)viaion-exchange. Drug release studies in phosphate buffered saline (pH = 7.4) revealed all three formulations release their drug cargo rapidly over the course of approximately 5 hours. In addition, solid state fluorescence studies indicated that fluorescence intensity is strongly dependent on the identity of the guest anion. It was postulated that this feature may be used to track the extent of drug release from the formulation, which was subsequently successfully demonstrated for the ibuprofen loaded LTbH. Overall, LTbH exhibits good biocompatibility, high drug loading, and a strong, guest-dependent fluorescence signal, all of which are desirable qualities for theranostic applications.

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Layered terbium hydroxides for simultaneous drug delivery and imaging

Abstract

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