Lactate trains immunity

Alba Llibre; Claudio Mauro

doi:10.1016/j.it.2025.05.002

Lactate trains immunity

Alba Llibre, Claudio Mauro^*

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Understanding the mechanisms implicated in the establishment of trained immunity could aid the design of novel therapeutic approaches. By studying Bacille Calmette-Guerin (BCG) vaccination in a human cohort, Ziogas and colleagues demonstrate the role of lactate generation and its use for histone lactylation as a key mechanism for establishing innate immune memory.

Original language	English
Journal	Trends in Immunology
DOIs	https://doi.org/10.1016/j.it.2025.05.002
Publication status	E-pub ahead of print - 26 May 2025

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.it.2025.05.002Licence: Creative Commons: Attribution (CC BY)

LlibreA2025LactateProof, 481 KBLicence: Creative Commons: Attribution (CC BY)

Investigating and exploiting lactate signalling in athero-immunometabolism
Mauro, C. (Principal Investigator)
British Heart Foundation
1/02/23 → 31/01/28
Project: Research

Cite this

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title = "Lactate trains immunity",

abstract = "Understanding the mechanisms implicated in the establishment of trained immunity could aid the design of novel therapeutic approaches. By studying Bacille Calmette-Guerin (BCG) vaccination in a human cohort, Ziogas and colleagues demonstrate the role of lactate generation and its use for histone lactylation as a key mechanism for establishing innate immune memory.",

author = "Alba Llibre and Claudio Mauro",

note = "Copyright {\textcopyright} 2025 The Author(s). Published by Elsevier Ltd.",

year = "2025",

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AU - Mauro, Claudio

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AB - Understanding the mechanisms implicated in the establishment of trained immunity could aid the design of novel therapeutic approaches. By studying Bacille Calmette-Guerin (BCG) vaccination in a human cohort, Ziogas and colleagues demonstrate the role of lactate generation and its use for histone lactylation as a key mechanism for establishing innate immune memory.

U2 - 10.1016/j.it.2025.05.002

DO - 10.1016/j.it.2025.05.002

M3 - Comment/debate

C2 - 40425374

SN - 1471-4906

JO - Trends in Immunology

JF - Trends in Immunology

ER -

Lactate trains immunity

Abstract

Bibliographical note

UN SDGs

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Projects

Investigating and exploiting lactate signalling in athero-immunometabolism

Cite this