Lactate: fueling the fire starter

Michelangelo Certo, Giancarlo Marone, Amato de Paulis, Claudio Mauro, Valentina Pucino

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)
242 Downloads (Pure)


It is becoming increasingly appreciated that intermediates of metabolic pathways, besides their anabolic and catabolic functions, can act as signaling molecules and influence the outcome of immune responses. Although lactate was previously considered as a waste product of glucose metabolism, accumulating evidence has highlighted its pivotal role in regulating diverse biological processes, including immune cell polarization, differentiation and effector functions. In addition, lactate is a key player in modulating tumor immune surveillance. Hence, targeting lactate‐induced signaling pathways is a promising tool to reduce inflammation, to prevent autoimmunity and to restore anti‐tumor immune response.
Original languageEnglish
Article numbere1474
Pages (from-to)1-15
Number of pages15
JournalWires Systems Biology and Medicine
Issue number3
Early online date16 Dec 2019
Publication statusPublished - 13 Apr 2020


  • immunity
  • inflammation
  • lactate
  • metabolism
  • tumor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)


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