Kinetic resolution of alkyne-substituted quaternary oxindoles via copper catalysed azide-alkyne cycloadditions

William D G Brittain, Benjamin R Buckley, John S Fossey

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)
170 Downloads (Pure)

Abstract

The synthesis and kinetic resolution of quaternary oxindoles through copper catalysed azide-alkyne cycloadditions is presented. Selectivity factors (s) up to 22.1 ± 0.5 are reported. Enantioenriched alkynes and triazoles were obtained in ≥80% enantiomeric excess (e.e.).

Original languageEnglish
Pages (from-to)17217-17220
JournalChemical Communications
Volume51
Issue number97
Early online date27 Aug 2015
DOIs
Publication statusPublished - 18 Dec 2015

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