Kinesin-8 motors improve nuclear centering by promoting microtubule catastrophe

Matko Glunčić, Nicola Maghelli, Alexander Krull, Vladimir Krstić, Damien Ramunno-Johnson, Nenad Pavin, Iva M Tolić

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


In fission yeast, microtubules push against the cell edge, thereby positioning the nucleus in the cell center. Kinesin-8 motors regulate microtubule catastrophe; however, their role in nuclear positioning is not known. Here we develop a physical model that describes how kinesin-8 motors affect nuclear centering by promoting a microtubule catastrophe. Our model predicts the improved centering of the nucleus in the presence of motors, which we confirmed experimentally in living cells. The model also predicts a characteristic time for the recentering of a displaced nucleus, which is supported by our experiments where we displaced the nucleus using optical tweezers
Original languageEnglish
Article number078103
Number of pages5
JournalPhysical Review Letters
Issue number7
Publication statusPublished - 18 Feb 2015


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