Kinesin-8 motors improve nuclear centering by promoting microtubule catastrophe

Matko Glunčić, Nicola Maghelli, Alexander Krull, Vladimir Krstić, Damien Ramunno-Johnson, Nenad Pavin, Iva M Tolić

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

In fission yeast, microtubules push against the cell edge, thereby positioning the nucleus in the cell center. Kinesin-8 motors regulate microtubule catastrophe; however, their role in nuclear positioning is not known. Here we develop a physical model that describes how kinesin-8 motors affect nuclear centering by promoting a microtubule catastrophe. Our model predicts the improved centering of the nucleus in the presence of motors, which we confirmed experimentally in living cells. The model also predicts a characteristic time for the recentering of a displaced nucleus, which is supported by our experiments where we displaced the nucleus using optical tweezers
Original languageEnglish
Article number078103
Number of pages5
JournalPhysical Review Letters
Volume114
Issue number7
DOIs
Publication statusPublished - 18 Feb 2015

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