KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia

Thoraia Shinawi, V Hill, A Dagklis, P Baliakas, K Stamatopoulos, A Agathanggelou, Tatjana Stankovic, Eamonn Maher, P Ghia, Farida Latif

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Ras-association domain family (RASSF) members are a family of genes containing an RA domain in either the C-terminus (RASSF1-RASSF6) or in the N-terminus (RASSF7-RASSF10). Members of this gene family are core members of the Salvador/Warts/Hippo (SWH) tumor suppressor network and have been shown to be involved in human tumorigenesis. Among the RASSF genes, RASSF1A is one of the most frequently methylated genes in a wide range of epithelial cancers, and we previously demonstrated that RASSF6 and RASSF10 genes are frequently epigenetically inactivated in acute leukemias, particularly in those of the B cell type. We here determined the methylation profiles of all members of the RASSF gene family as well as two recently identified (KIBRA, CRB3) upstream members of the SWH pathway in the leukemic B cells obtained from a well-characterized cohort of 95 patients with chronic lymphocytic leukemia (CLL). Among the RASSF genes, RASSF10 (50%) was the most frequently methylated gene, followed by RASSF6 (16%). The remaining RASSF genes were either unmethylated or showed a frequency of methylation
Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalEpigenetics : official journal of the DNA Methylation Society
Volume7
Issue number3
DOIs
Publication statusPublished - 1 Mar 2012

Keywords

  • prognostic marker
  • KIBRA
  • SWH pathway
  • RASSF genes
  • DNA methylation
  • chronic lymphocytic leukemia

Fingerprint

Dive into the research topics of 'KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia'. Together they form a unique fingerprint.

Cite this