TY - CHAP
T1 - Key Roles for AMP-activated Protein Kinase in the Function of the Carotid Body?
AU - Wyatt, CN
AU - Pearson, Selina
AU - Kumar, Prem
AU - Peers, C
AU - Hardie, DG
AU - Evans, AM
PY - 2008/1/1
Y1 - 2008/1/1
N2 - The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphate-activated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.
AB - The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphate-activated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.
U2 - 10.1007/978-0-387-73693-8_11
DO - 10.1007/978-0-387-73693-8_11
M3 - Chapter
C2 - 18085248
VL - 605
T3 - Advances in Experimental Medicine and Biology
BT - Advances in experimental medicine and biology
ER -