We present an operationally simple iterative coupling strategy for the synthesis of oligomeric homo- and hetero[n]rotaxanes with precise control over the position of each macrocycle. The exceptional yield of the AT-CuAAC reaction, combined with optimized conditions that allow the rapid synthesis of the target oligomers, opens the door to the study of precision-engineered oligomeric interlocked molecules.
Bibliographical noteFunding Information:
The authors are grateful to Fluorochem for the gift of reagents. High-resolution mass spectrometry analysis was carried out by the EPSRC National Spectrometry Facility. This work was supported financially by the Royal Society, the European Union, and the EPSRC (EP/J01981X/1). This project has received funding from the European Unions Horizon 2020 research and innovation programme under the Marie Sk?odowska-Curie grant agreement no. 660731. J.E.M.L. is an EU Marie Sklodowska-Curie Fellow. S.M.G. is a Royal Society Research Fellow.
© 2016 American Chemical Society.
ASJC Scopus subject areas
- Colloid and Surface Chemistry