Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

Alexandra Pope; Christopher Bruce; Boris Kysela; Michael Hannon

doi:10.1039/b927129p

Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

Alexandra Pope, Christopher Bruce, Boris Kysela, Michael Hannon

Chemistry

Research output: Contribution to journal › Article

23 Citations (Scopus)

Abstract

Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.

Original language	English
Pages (from-to)	2772-2774
Number of pages	3
Journal	Dalton Transactions
Volume	39
Issue number	11
DOIs	https://doi.org/10.1039/b927129p
Publication status	Published - 1 Jan 2010

Access to Document

10.1039/b927129p

Maintaining Genome Stability: DNA Double Strand Break Repair Within Chromatin in Mammalian Cells
Kysela, B. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/06/05 → 31/05/08
Project: Research Councils

Cite this

@article{a74b4da931ea438084b1d13f2bea4a49,

title = "Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs",

abstract = "Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.",

author = "Alexandra Pope and Christopher Bruce and Boris Kysela and Michael Hannon",

year = "2010",

month = jan,

day = "1",

doi = "10.1039/b927129p",

language = "English",

volume = "39",

pages = "2772--2774",

journal = "Dalton Transactions",

issn = "1477-9234",

publisher = "Royal Society of Chemistry",

number = "11",

}

TY - JOUR

T1 - Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

AU - Pope, Alexandra

AU - Bruce, Christopher

AU - Kysela, Boris

AU - Hannon, Michael

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.

AB - Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.

U2 - 10.1039/b927129p

DO - 10.1039/b927129p

M3 - Article

C2 - 20200702

SN - 1477-9234

VL - 39

SP - 2772

EP - 2774

JO - Dalton Transactions

JF - Dalton Transactions

IS - 11

ER -

Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

Abstract

Access to Document

Fingerprint

Projects

Maintaining Genome Stability: DNA Double Strand Break Repair Within Chromatin in Mammalian Cells

Cite this