Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin?: A preliminary case control study

Jeetesh V Patel; Julia Chackathayil; Brian Gammon; Inessa Tracey; Adam Lovick; Paramjit S Gill; Amitava Banerjee; Charlotte A Scarff; James H Scrivens; Gregory Y H Lip; Elizabeth A Hughes

doi:10.1016/j.atherosclerosis.2012.09.017

Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study

Jeetesh V Patel
, Julia Chackathayil
, Brian Gammon
, Inessa Tracey
, Adam Lovick
, Paramjit S Gill
, Amitava Banerjee
, Charlotte A Scarff
, James H Scrivens
, Gregory Y H Lip
, Elizabeth A Hughes

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The elevated burden of cardiovascular disease (CVD) amongst South Asian populations is a complex and multi-factorial phenomenon. South Asians evolved from environments where malaria was endemic, and while haemoglobin disorders frequent this group, a link to CVD has not been described. Using a case-control feasibility study, haemoglobin abnormalities identified by mass spectrometry were compared between South Asian patients with CVD (n = 72) and non-CVD controls (n = 84). Carotid-artery intima media thickness (CIMT) was used as a marker of vascular damage. Ultracentrifugation was used to separate lipoprotein subfractions, which were analysed for iron. Haemoglobin anomalies were more frequent for CVD patients than controls (34.7% vs. 14.3%, P

Original language	English
Pages (from-to)	198-200
Number of pages	3
Journal	Atherosclerosis
Volume	226
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2012.09.017
Publication status	Published - 2013

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10.1016/j.atherosclerosis.2012.09.017

Cite this

Patel, J. V., Chackathayil, J., Gammon, B., Tracey, I., Lovick, A., Gill, P. S., Banerjee, A., Scarff, C. A., Scrivens, J. H., Lip, G. Y. H., & Hughes, E. A. (2013). Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study. Atherosclerosis, 226(1), 198-200. https://doi.org/10.1016/j.atherosclerosis.2012.09.017

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title = "Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin?: A preliminary case control study",

abstract = "The elevated burden of cardiovascular disease (CVD) amongst South Asian populations is a complex and multi-factorial phenomenon. South Asians evolved from environments where malaria was endemic, and while haemoglobin disorders frequent this group, a link to CVD has not been described. Using a case-control feasibility study, haemoglobin abnormalities identified by mass spectrometry were compared between South Asian patients with CVD (n = 72) and non-CVD controls (n = 84). Carotid-artery intima media thickness (CIMT) was used as a marker of vascular damage. Ultracentrifugation was used to separate lipoprotein subfractions, which were analysed for iron. Haemoglobin anomalies were more frequent for CVD patients than controls (34.7\% vs. 14.3\%, P ",

author = "Patel, \{Jeetesh V\} and Julia Chackathayil and Brian Gammon and Inessa Tracey and Adam Lovick and Gill, \{Paramjit S\} and Amitava Banerjee and Scarff, \{Charlotte A\} and Scrivens, \{James H\} and Lip, \{Gregory Y H\} and Hughes, \{Elizabeth A\}",

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doi = "10.1016/j.atherosclerosis.2012.09.017",

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Patel, JV, Chackathayil, J, Gammon, B, Tracey, I, Lovick, A, Gill, PS, Banerjee, A, Scarff, CA, Scrivens, JH, Lip, GYH & Hughes, EA 2013, 'Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study', Atherosclerosis, vol. 226, no. 1, pp. 198-200. https://doi.org/10.1016/j.atherosclerosis.2012.09.017

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T1 - Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin?

T2 - A preliminary case control study

AU - Patel, Jeetesh V

AU - Chackathayil, Julia

AU - Gammon, Brian

AU - Tracey, Inessa

AU - Lovick, Adam

AU - Gill, Paramjit S

AU - Banerjee, Amitava

AU - Scarff, Charlotte A

AU - Scrivens, James H

AU - Lip, Gregory Y H

AU - Hughes, Elizabeth A

PY - 2013

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AB - The elevated burden of cardiovascular disease (CVD) amongst South Asian populations is a complex and multi-factorial phenomenon. South Asians evolved from environments where malaria was endemic, and while haemoglobin disorders frequent this group, a link to CVD has not been described. Using a case-control feasibility study, haemoglobin abnormalities identified by mass spectrometry were compared between South Asian patients with CVD (n = 72) and non-CVD controls (n = 84). Carotid-artery intima media thickness (CIMT) was used as a marker of vascular damage. Ultracentrifugation was used to separate lipoprotein subfractions, which were analysed for iron. Haemoglobin anomalies were more frequent for CVD patients than controls (34.7% vs. 14.3%, P

U2 - 10.1016/j.atherosclerosis.2012.09.017

DO - 10.1016/j.atherosclerosis.2012.09.017

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VL - 226

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JO - Atherosclerosis

JF - Atherosclerosis

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