Is the abundance of Faecalibacterium prausnitzii relevant to Crohn's disease?

Wenjing Jia, Rebekah Whitehead, Lesley Griffiths, C Dawson, Rosemary Waring, David Ramsden, JO Hunter, Jeffrey Cole

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67 Citations (Scopus)
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Abstract

Reports that bacteria within the Firmicutes phylum, especially the species Faecalibacterium prausnitzii, are less abundant in Crohn’s disease (CD) patients and supernatants from cultures of this bacterium are anti-inflammatory prompted the investigation of the possible correlations between the abundance of F.prausnitzii and the response to treatment in patients with gut diseases and healthy controls. In a randomized, double-blind trial, faeces were collected from healthy volunteers, and from patients with active CD, ulcerative colitis (UC) and irritable bowel syndrome before and after treatment. The levels of F. prausnitzii DNA in faecal suspensions were determined by PCR. Treatment by an elemental diet was effective, resulting in decreases in both the Harvey and Bradshaw index (P
Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalFEMS Microbiology Letters
Volume310
Issue number2
DOIs
Publication statusPublished - 1 Sep 2010

Keywords

  • Crohn's disease
  • ulcerative colitis
  • Faecalibacterium prausnitzii
  • irritable bowel syndrome
  • faecal bacteria
  • butyrate

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