Iron deficiency and immune responses

G O Latunde-Dada, S P Young

Research output: Contribution to journalArticlepeer-review


Iron deficiency is often associated with the impairment of the immune system, particularly the functioning of T-cell lymphocytes. Studies were therefore carried out in mice to investigate the involvement of iron in T-cell functions. Iron deficiency in mice was induced nutritionally by feeding diets differing in iron content for 4 weeks to produce normal, moderately low and severely low haematological indices. The proliferation of lymphocytes stimulated by Con A from these groups of mice was significantly affected by the degree of iron deficiency. Iron depletion also resulted in decreased production of interleukin 2 (IL-2) in the proliferating cells. The implications of these findings in the manifestation of iron deficiency anaemia are discussed.
Original languageEnglish
Pages (from-to)207-9
Number of pages3
JournalScandinavian journal of immunology. Supplement
Publication statusPublished - 1992


  • Lymphocyte Activation
  • Animals
  • Interleukin-2
  • DNA
  • Mice
  • Mice, Inbred BALB C
  • Iron


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