IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria

Meike Baumgart; Kerstin Luder; Shipra Grover; Cornelia Gätgens; Gurdyal S Besra; Julia Frunzke

doi:10.1186/1741-7007-11-122

IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria

Meike Baumgart, Kerstin Luder, Shipra Grover, Cornelia Gätgens, Gurdyal S Besra, Julia Frunzke

Biosciences

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Abstract

The development of new drugs against tuberculosis and diphtheria is focused on disrupting the biogenesis of the cell wall, the unique architecture of which confers resistance against current therapies. The enzymatic pathways involved in the synthesis of the cell wall by these pathogens are well understood but the underlying regulatory mechanisms are largely unknown.

Original language	English
Article number	122
Journal	BMC Biology
Volume	11
DOIs	https://doi.org/10.1186/1741-7007-11-122
Publication status	Published - 30 Dec 2013

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10.1186/1741-7007-11-122

Baumgart_et_al_IpsA_Novel_Lacl-type_BMC_Biology_2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Checked July 2015
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title = "IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria",

abstract = "The development of new drugs against tuberculosis and diphtheria is focused on disrupting the biogenesis of the cell wall, the unique architecture of which confers resistance against current therapies. The enzymatic pathways involved in the synthesis of the cell wall by these pathogens are well understood but the underlying regulatory mechanisms are largely unknown.",

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AU - Luder, Kerstin

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AU - Gätgens, Cornelia

AU - Besra, Gurdyal S

AU - Frunzke, Julia

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AB - The development of new drugs against tuberculosis and diphtheria is focused on disrupting the biogenesis of the cell wall, the unique architecture of which confers resistance against current therapies. The enzymatic pathways involved in the synthesis of the cell wall by these pathogens are well understood but the underlying regulatory mechanisms are largely unknown.

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ER -

IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria

Abstract

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