Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

Medicine & Life Sciences

• Intestines 100%
• Alleles 80%
• Mutation 61%
• Loss of Function Mutation 41%
• Polyps 37%
• Neoplasms 35%
• Adenoma 34%
• Cyclin E 23%
• Breeding 21%
• Ligases 20%
• Missense Mutation 18%
• Ubiquitin 18%
• Arginine 16%
• Colorectal Neoplasms 14%
• Carcinogenesis 14%
• Animal Models 13%
• Phenotype 11%
• Morbidity 10%
• Growth 9%
• Animals 9%