Investigation of community carriage rates of Clostridium difficile and Hungatella hathewayi in healthy volunteers from four regions of England

S. E. Manzoor; C. A. M. McNulty; D. Nakiboneka-Ssenabulya; D. M. Lecky; Katie Hardy; Peter Hawkey

doi:10.1016/j.jhin.2017.05.014

Investigation of community carriage rates of Clostridium difficile and Hungatella hathewayi in healthy volunteers from four regions of England

S. E. Manzoor, C. A. M. McNulty, D. Nakiboneka-Ssenabulya, D. M. Lecky, Katie Hardy, Peter Hawkey

Microbiology and Infection

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Abstract

Faecal samples from 1365 healthy asymptomatic volunteers from four regions in England were screened for the presence of Clostridium difficile between December 2013 and July 2014. The carriage rate of C. difficile in healthy patients was 0.5%, which is lower than previously reported. This study demonstrates that the true community reservoir of C. difficile in the healthy UK population is very low and is, therefore, unlikely to be a reservoir for infections diagnosed in the hospital setting.

Original language	English
Pages (from-to)	153-155
Number of pages	3
Journal	The Journal of hospital infection
Volume	97
Issue number	2
Early online date	23 May 2017
DOIs	https://doi.org/10.1016/j.jhin.2017.05.014
Publication status	Published - Oct 2017

Keywords

Adult
Carrier State/microbiology
Clostridium/isolation & purification
Clostridium Infections/diagnosis
Clostridium difficile/isolation & purification
England/epidemiology
Feces/microbiology
Healthy Volunteers
Humans
Polymerase Chain Reaction
State Medicine
Young Adult

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Manzoor, S. E., McNulty, C. A. M., Nakiboneka-Ssenabulya, D., Lecky, D. M., Hardy, K., & Hawkey, P. (2017). Investigation of community carriage rates of Clostridium difficile and Hungatella hathewayi in healthy volunteers from four regions of England. The Journal of hospital infection, 97(2), 153-155. Advance online publication. https://doi.org/10.1016/j.jhin.2017.05.014

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title = "Investigation of community carriage rates of Clostridium difficile and Hungatella hathewayi in healthy volunteers from four regions of England",

abstract = "Faecal samples from 1365 healthy asymptomatic volunteers from four regions in England were screened for the presence of Clostridium difficile between December 2013 and July 2014. The carriage rate of C. difficile in healthy patients was 0.5%, which is lower than previously reported. This study demonstrates that the true community reservoir of C. difficile in the healthy UK population is very low and is, therefore, unlikely to be a reservoir for infections diagnosed in the hospital setting.",

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author = "Manzoor, {S. E.} and McNulty, {C. A. M.} and D. Nakiboneka-Ssenabulya and Lecky, {D. M.} and Katie Hardy and Peter Hawkey",

year = "2017",

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doi = "10.1016/j.jhin.2017.05.014",

language = "English",

volume = "97",

pages = "153--155",

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T1 - Investigation of community carriage rates of Clostridium difficile and Hungatella hathewayi in healthy volunteers from four regions of England

AU - Manzoor, S. E.

AU - McNulty, C. A. M.

AU - Nakiboneka-Ssenabulya, D.

AU - Lecky, D. M.

AU - Hardy, Katie

AU - Hawkey, Peter

PY - 2017/10

Y1 - 2017/10

N2 - Faecal samples from 1365 healthy asymptomatic volunteers from four regions in England were screened for the presence of Clostridium difficile between December 2013 and July 2014. The carriage rate of C. difficile in healthy patients was 0.5%, which is lower than previously reported. This study demonstrates that the true community reservoir of C. difficile in the healthy UK population is very low and is, therefore, unlikely to be a reservoir for infections diagnosed in the hospital setting.

AB - Faecal samples from 1365 healthy asymptomatic volunteers from four regions in England were screened for the presence of Clostridium difficile between December 2013 and July 2014. The carriage rate of C. difficile in healthy patients was 0.5%, which is lower than previously reported. This study demonstrates that the true community reservoir of C. difficile in the healthy UK population is very low and is, therefore, unlikely to be a reservoir for infections diagnosed in the hospital setting.

KW - Adult

KW - Carrier State/microbiology

KW - Clostridium/isolation & purification

KW - Clostridium Infections/diagnosis

KW - Clostridium difficile/isolation & purification

KW - England/epidemiology

KW - Feces/microbiology

KW - Healthy Volunteers

KW - Humans

KW - Polymerase Chain Reaction

KW - State Medicine

KW - Young Adult

U2 - 10.1016/j.jhin.2017.05.014

DO - 10.1016/j.jhin.2017.05.014

M3 - Article

C2 - 28549779

SN - 0195-6701

VL - 97

SP - 153

EP - 155

JO - The Journal of hospital infection

JF - The Journal of hospital infection

IS - 2

ER -

Investigation of community carriage rates of Clostridium difficile and Hungatella hathewayi in healthy volunteers from four regions of England

Abstract

Keywords

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