Investigation methods for cardiac autonomic function in human research studies

L Bernardi, V Spallone, Martin Stevens, J Hilsted, S Frontoni, R Pop-Busui, D Ziegler, P Kempler, R Freeman, P Low, S Tesfaye, P Valensi

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    94 Citations (Scopus)


    This consensus document provides evidence-based guidelines regarding the evaluation of diabetic cardiovascular autonomic neuropathy (CAN) for human research studies as a result of the work of the CAN Subcommittee of the Toronto Diabetic Neuropathy Expert Group. The CAN subcommittee critically reviewed the limitations and strengths of the available diagnostic approaches for CAN and the need for developing new tests for autonomic function. It was concluded that the most sensitive and specific approaches currently available to evaluate CAN in clinical research are: 1) heart rate variability, 2) baroreflex sensitivity, 3) muscle sympathetic nerve activity, 4) plasma catecholamines, and 5) heart sympathetic imaging. It was also recommended that efforts should be undertaken to develop new non-invasive and safe CAN tests to be used in clinical research, with a higher sensitivity and specificity, for studying the pathophysiology of CAN and new therapeutic approaches. Copyright © 2011 John Wiley & Sons, Ltd.
    Original languageEnglish
    JournalDiabetes/metabolism research and reviews
    Publication statusPublished - 21 Jun 2011


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