Inverse relationship between plasma von Willebrand factor and soluble P selectin in patients with type 1 but not type 2 von Willebrand disease

Andrew Blann, IC Nitu-Whalley, CA Lee, Gregory Lip

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

P selectin is a component of endothelial Wiebel-Palade body membrane and platelet alpha granule membrane. Patients with von Willebrand disease (VWD) have low plasma von Willebrand factor (VWF). To examine the relationship between plasma P selectin and VWF, both were measured by ELISA in 38 patients with VWD and 40 controls. The patient had lower VWF (P <0.001) but similar P selectin levels (P = 0.458). In 24 type 1 VWD patients, VWF and P selectin correlated inversely (P = 0.005) but in 14 type 2 VWD patients there was no correlation (P = 0.997). These data imply major differences in VWF/P-selectin regulation between types 1 and 2 VWD.
Original languageEnglish
Pages (from-to)135-7
Number of pages3
JournalAmerican Journal of Hematology
Volume69
Issue number2
DOIs
Publication statusPublished - 1 Feb 2002

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