Introduction to Lymphocyte Trafficking in Disease

Patricia F. Lalor; Elizabeth A Hepburn

doi:10.1007/978-1-4939-6931-9_12

Introduction to Lymphocyte Trafficking in Disease

Patricia F. Lalor, Elizabeth A Hepburn

Immunology and Immunotherapy

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

3 Citations (Scopus)

Abstract

Lymphocytes are the key effector cells of the adaptive immune response but are also implicated in the development of chronic inflammatory diseases such as type 2 diabetes, cardiovascular disease, inflammatory bowel disease, and allergy. In order to understand the mechanisms responsible for the global increase in such debilitating conditions it is vital to appreciate the complexity of immune cell trafficking into tissue under normal and inflamed conditions. In this chapter we introduce the mechanisms of immune cell recruitment into tissue and highlight how these processes have been targeted by new therapeutic entities based on blocking integrin or chemokine function.

Original language	English
Title of host publication	T-Cell Trafficking:
Subtitle of host publication	Methods and Protocols
Editors	George Edward Rainger, Helen M. Mcgettrick
Publisher	Springer
Pages	169-176
Number of pages	8
Volume	1591
ISBN (Electronic)	978-1-4939-6931-9
ISBN (Print)	978-1-4939-6929-6
DOIs	https://doi.org/10.1007/978-1-4939-6931-9_12
Publication status	Published - 28 Mar 2017

Publication series

Name	Methods in Molecular Biology
Publisher	Springer
ISSN (Print)	1064-3745

Keywords

Journal Article
inflammation
lymphocyte
migration
therapy
imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4939-6931-9_12Licence: None: All rights reserved

https://link.springer.com/protocol/10.1007%2F978-1-4939-6931-9_12Licence: None: All rights reserved

Cite this

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AU - Hepburn, Elizabeth A

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AB - Lymphocytes are the key effector cells of the adaptive immune response but are also implicated in the development of chronic inflammatory diseases such as type 2 diabetes, cardiovascular disease, inflammatory bowel disease, and allergy. In order to understand the mechanisms responsible for the global increase in such debilitating conditions it is vital to appreciate the complexity of immune cell trafficking into tissue under normal and inflamed conditions. In this chapter we introduce the mechanisms of immune cell recruitment into tissue and highlight how these processes have been targeted by new therapeutic entities based on blocking integrin or chemokine function.

KW - Journal Article

KW - inflammation

KW - lymphocyte

KW - migration

KW - therapy

KW - imaging

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DO - 10.1007/978-1-4939-6931-9_12

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A2 - Mcgettrick, Helen M.

PB - Springer

ER -

Introduction to Lymphocyte Trafficking in Disease

Abstract

Publication series

Keywords

UN SDGs

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