Introduction to Lymphocyte Trafficking in Disease

Patricia F. Lalor, Elizabeth A Hepburn

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

3 Citations (Scopus)


Lymphocytes are the key effector cells of the adaptive immune response but are also implicated in the development of chronic inflammatory diseases such as type 2 diabetes, cardiovascular disease, inflammatory bowel disease, and allergy. In order to understand the mechanisms responsible for the global increase in such debilitating conditions it is vital to appreciate the complexity of immune cell trafficking into tissue under normal and inflamed conditions. In this chapter we introduce the mechanisms of immune cell recruitment into tissue and highlight how these processes have been targeted by new therapeutic entities based on blocking integrin or chemokine function.

Original languageEnglish
Title of host publicationT-Cell Trafficking:
Subtitle of host publicationMethods and Protocols
EditorsGeorge Edward Rainger, Helen M. Mcgettrick
Number of pages8
ISBN (Electronic)978-1-4939-6931-9
ISBN (Print)978-1-4939-6929-6
Publication statusPublished - 28 Mar 2017

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Journal Article
  • inflammation
  • lymphocyte
  • migration
  • therapy
  • imaging


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