Introduction of a mutation in the shutter region of antithrombin (Phe77--> Leu) increases affinity for herarin and decreases thermal stability

NS Quinsey; HL Fitton; P Coughlin; JC Whisstock; Timothy Dafforn; RW Carrell; SP Bottomley

doi:10.1021/bi0349322

Introduction of a mutation in the shutter region of antithrombin (Phe77--> Leu) increases affinity for herarin and decreases thermal stability

NS Quinsey
, HL Fitton
, P Coughlin
, JC Whisstock
, Timothy Dafforn
, RW Carrell
, SP Bottomley

Research output: Contribution to journal › Article

6 Citations (Scopus)

Original language	English
Pages (from-to)	10169-10173
Number of pages	5
Journal	Biochemistry
Volume	42
DOIs	https://doi.org/10.1021/bi0349322
Publication status	Published - 2 Sept 2003

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10.1021/bi0349322

Cite this

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title = "Introduction of a mutation in the shutter region of antithrombin (Phe77--> Leu) increases affinity for herarin and decreases thermal stability",

author = "NS Quinsey and HL Fitton and P Coughlin and JC Whisstock and Timothy Dafforn and RW Carrell and SP Bottomley",

year = "2003",

month = sep,

day = "2",

doi = "10.1021/bi0349322",

language = "English",

volume = "42",

pages = "10169--10173",

journal = "Biochemistry",

issn = "1520-4995",

publisher = "American Chemical Society",

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AU - Quinsey, NS

AU - Fitton, HL

AU - Coughlin, P

AU - Whisstock, JC

AU - Dafforn, Timothy

AU - Carrell, RW

AU - Bottomley, SP

PY - 2003/9/2

Y1 - 2003/9/2

UR - https://www.scopus.com/pages/publications/0041322939

U2 - 10.1021/bi0349322

DO - 10.1021/bi0349322

M3 - Article

C2 - 12939144

SN - 1520-4995

VL - 42

SP - 10169

EP - 10173

JO - Biochemistry

JF - Biochemistry

ER -