Intimin and the host cell - is it bound to end in Tir(s)?

G Frankel, AD Phillips, LR Trabulsi, Stuart Knutton, G Dougan, S Matthews

    Research output: Contribution to journalArticle

    85 Citations (Scopus)


    Intimate bacterial adhesion to the intestinal epithelium is a pathogenic mechanism shared by several human and animal enteric pathogens, including enteropathogenic and enterohaemorrhagic Escherichia coli. Two bacterial protein partners involved in this intimate association have been identified, intimin and Tir. Some key remaining questions include whether intimin specifically interacts with one or more host-cell-encoded molecules and whether these contacts are a prerequisite for the subsequent intimate intimin-Tir association. Recent data support the hypothesis that the formation of a stable intimin-Tir relationship is the consequence of intimin protein interactions involving both host end bacterial components.
    Original languageEnglish
    Pages (from-to)214-218
    Number of pages5
    JournalTrends in Microbiology
    Issue number5
    Publication statusPublished - 1 May 2001


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