Intestinal secretory and absorptive function in Trichinella spiralis mouse model of postinfective gut dysfunction: role of bile acids

N Kalia, J Hardcastle, C Keating, L Grasa, C Keating, P Pelegrin, K D Bardhan, D Grundy

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Observations showing that bile acid malabsorption is frequent in irritable bowel syndrome (IBS) suggest that alterations in bile acid-induced secretion and absorption could contribute to IBS-associated diarrhoea. The secretory response to bile acids, fluid transport and bile absorption was examined in intestinal tissues from a Trichinella spiralis mouse model of postinfectious gut dysfunction in vitro. Changes in the protein expression of apical sodium-dependent bile acid transporter (ASBT) were also measured.
Original languageEnglish
Pages (from-to)41-9
Number of pages9
JournalGut
Volume57
Issue number1
Publication statusPublished - 2008

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