Interrelationships between heath utility measurements, disease activity and psychological factors in Behçet's disease

Phil Murray, Anisha Sekaran, Hedayat Javidi, Deva Situnayake

Research output: Contribution to journalArticlepeer-review

46 Downloads (Pure)


Objective: To measure the health utilities Time Trade-Off (TTO) and Standard Gamble (SG), that ask to consider sacrifices in terms of length of life (TTO) or risk of death (SG) for improvements in quality of life in Behcet's disease (BD), and explore the interrelationships with disease activity, depression, anxiety and fatigue.

Method: TTO, SG, EQ-5D-5L, EQ VAS, depression (PHQ-9), anxiety (GAD-7) and fatigue (MAF) questionnaires were administered to 103 adult BD patients. Disease activity was assessed using the Behçet's Disease Activity Index (BDAI).

Results: Mean TTO was 0.72 ± SD 0.27 and mean SG 0.70 ± SD 0.34. Moderate/severe depression was identified in 55.2%, moderate/severe anxiety in 35.1% and moderate/high fatigue in 97.7% patients. TTO negatively correlated with depression (p < 0.01), anxiety (p < 0.01) and fatigue (p < 0.01) but did not correlate with BDAI. Cluster analysis revealed one cluster where psychological factors rather than disease activity may have influenced TTO and SG scores.

Conclusions: TTO and SG show that BD patients would on average forgo 28% of their remaining life or run a 30% risk of death to avoid the condition. Complex interrelationships with depression, anxiety and fatigue may be more influential than disease activity in treatment decision making.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalGeneral Hospital Psychiatry
Issue numberMay-June
Publication statusPublished - 5 Mar 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.


  • Anxiety
  • Behçet's disease
  • Depression
  • Disease activity
  • Fatigue
  • Healthcare quality indicators

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Interrelationships between heath utility measurements, disease activity and psychological factors in Behçet's disease'. Together they form a unique fingerprint.

Cite this