Interpreting results from biomarker-guided clinical trials: avoiding “negative” or “failed” terminology

Nurulamin m. Noor; Haiyan Zheng; David Robertson; Joshua Savage; Christina Yap; Andrea l. Jorgensen; James m. s. Wason; MRC-NIHR Trial methodology Research Partnership (TMRP) Precision Medicine Working Group

doi:10.1186/s12916-025-04035-9

Interpreting results from biomarker-guided clinical trials: avoiding “negative” or “failed” terminology

Nurulamin m. Noor
, Haiyan Zheng
, David Robertson
, Joshua Savage
, Christina Yap
, Andrea l. Jorgensen
, James m. s. Wason^*
, MRC-NIHR Trial methodology Research Partnership (TMRP) Precision Medicine Working Group

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

49 Downloads (Pure)

Original language	English
Journal	BMC medicine
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s12916-025-04035-9
Publication status	Published - 28 May 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

clinical trial
biomarker
methodology

ASJC Scopus subject areas

Medicine(all)
Medicine (miscellaneous)

Access to Document

10.1186/s12916-025-04035-9Licence: Creative Commons: Attribution (CC BY)

Noor2025InterpretingFinal published version, 655 KBLicence: Creative Commons: Attribution (CC BY)

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-04035-9

Cite this

@article{1c7576d4ca1b45bbbee12b36230f2aeb,

title = "Interpreting results from biomarker-guided clinical trials: avoiding “negative” or “failed” terminology",

keywords = "clinical trial, biomarker, methodology",

author = "Noor, \{Nurulamin m.\} and Haiyan Zheng and David Robertson and Joshua Savage and Christina Yap and Jorgensen, \{Andrea l.\} and Wason, \{James m. s.\} and \{MRC-NIHR Trial methodology Research Partnership (TMRP) Precision Medicine Working Group\}",

year = "2025",

month = may,

day = "28",

doi = "10.1186/s12916-025-04035-9",

language = "English",

volume = "23",

journal = "BMC medicine",

issn = "1741-7015",

publisher = "Springer",

number = "1",

}

TY - JOUR

T1 - Interpreting results from biomarker-guided clinical trials: avoiding “negative” or “failed” terminology

AU - Noor, Nurulamin m.

AU - Zheng, Haiyan

AU - Robertson, David

AU - Savage, Joshua

AU - Yap, Christina

AU - Jorgensen, Andrea l.

AU - Wason, James m. s.

AU - MRC-NIHR Trial methodology Research Partnership (TMRP) Precision Medicine Working Group

PY - 2025/5/28

Y1 - 2025/5/28

KW - clinical trial

KW - biomarker

KW - methodology

U2 - 10.1186/s12916-025-04035-9

DO - 10.1186/s12916-025-04035-9

M3 - Comment/debate

SN - 1741-7015

VL - 23

JO - BMC medicine

JF - BMC medicine

IS - 1

ER -