TY - JOUR
T1 - Interobserver variation in the interpretation of magnetic resonance enterography in Crohn's disease
AU - METRIC study investigators
AU - Bhatnagar, Gauraang
AU - Mallett, Sue
AU - Quinn, Laura
AU - Beable, Richard
AU - Bungay, Helen
AU - Betts, Margaret
AU - Greenhalgh, Rebecca
AU - Gupta, Arun
AU - Higginson, Anthony
AU - Hyland, Rachel
AU - Ilangovan, Rajapandian
AU - Lambie, Hannah
AU - Mainta, Evgenia
AU - Patel, Uday
AU - Pilcher, James
AU - Plumb, Andrew
AU - Porté, François
AU - Sidhu, Harbir
AU - Slater, Andrew
AU - Tolan, Damian
AU - Zealley, Ian
AU - Halligan, Steve
AU - Taylor, Stuart
PY - 2022/6/1
Y1 - 2022/6/1
N2 - OBJECTIVES: To evaluate interobserver variability for diagnosis of disease presence and extent of small bowel and colonic Crohn's disease using MR enterography (MRE).METHODS: Data from the first 73 consecutive patients (mean age 32, 33F, 28 new diagnosis, 45 suspected relapse) recruited to a multicentre, prospective diagnostic accuracy trial evaluating MRE for small bowel Crohn's disease were each read independently by three (from a pool of 20) radiologists. Radiologists documented presence and segmental location of small bowel Crohn's disease and recorded morphological mural/extramural parameters for involved segments. Per patient percentage agreement for disease presence and extent were calculated against an outcome-based construct reference standard (averaged between pairs of readers). Prevalence-adjusted bias-adjusted κ (PABAK) was calculated.RESULTS: Agreement for small bowel disease presence for new diagnosis/relapsed patients was 68%(κ = 0.36)/ 78% (κ = 0.56) and 43%(κ = 0.14)/ 53% for disease extent (κ = 0.07), respectively. For disease presence, all three radiologists agreed correctly with the reference standard in 41/59 (69%) of patients with small bowel involvement, and in 8/14 (57%) cases of without small bowel disease. Agreement was highest for multisegment disease, greater than 5 cm in length, with mural thickness>6 mm, and increased mural T2 signal. Agreement for colonic disease presence was 61% (κ = 0.21 fair agreement) for new diagnosis/ 60% (κ = 0.20, slight agreement) for relapsed patients.CONCLUSION: There is a reasonable agreement between radiologists for small bowel disease presence using MRE for newly diagnosed Crohn's disease, and patients with suspected relapse, respectively. Agreement is lower for disease extent.ADVANCES IN KNOWLEDGE: There is reasonable agreement between radiologists for small bowel disease presence using MRE for newly diagnosed (68%) Crohn's disease, and patients with suspected relapse (78%). Agreement is lower for disease extent (43% new diagnosis and 53% suspected relapse).
AB - OBJECTIVES: To evaluate interobserver variability for diagnosis of disease presence and extent of small bowel and colonic Crohn's disease using MR enterography (MRE).METHODS: Data from the first 73 consecutive patients (mean age 32, 33F, 28 new diagnosis, 45 suspected relapse) recruited to a multicentre, prospective diagnostic accuracy trial evaluating MRE for small bowel Crohn's disease were each read independently by three (from a pool of 20) radiologists. Radiologists documented presence and segmental location of small bowel Crohn's disease and recorded morphological mural/extramural parameters for involved segments. Per patient percentage agreement for disease presence and extent were calculated against an outcome-based construct reference standard (averaged between pairs of readers). Prevalence-adjusted bias-adjusted κ (PABAK) was calculated.RESULTS: Agreement for small bowel disease presence for new diagnosis/relapsed patients was 68%(κ = 0.36)/ 78% (κ = 0.56) and 43%(κ = 0.14)/ 53% for disease extent (κ = 0.07), respectively. For disease presence, all three radiologists agreed correctly with the reference standard in 41/59 (69%) of patients with small bowel involvement, and in 8/14 (57%) cases of without small bowel disease. Agreement was highest for multisegment disease, greater than 5 cm in length, with mural thickness>6 mm, and increased mural T2 signal. Agreement for colonic disease presence was 61% (κ = 0.21 fair agreement) for new diagnosis/ 60% (κ = 0.20, slight agreement) for relapsed patients.CONCLUSION: There is a reasonable agreement between radiologists for small bowel disease presence using MRE for newly diagnosed Crohn's disease, and patients with suspected relapse, respectively. Agreement is lower for disease extent.ADVANCES IN KNOWLEDGE: There is reasonable agreement between radiologists for small bowel disease presence using MRE for newly diagnosed (68%) Crohn's disease, and patients with suspected relapse (78%). Agreement is lower for disease extent (43% new diagnosis and 53% suspected relapse).
KW - Adult
KW - Clinical Trials as Topic
KW - Crohn Disease/diagnostic imaging
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Magnetic Resonance Spectroscopy
KW - Male
KW - Multicenter Studies as Topic
KW - Observer Variation
KW - Prospective Studies
KW - Recurrence
UR - http://www.scopus.com/inward/record.url?scp=85130863270&partnerID=8YFLogxK
U2 - 10.1259/bjr.20210995
DO - 10.1259/bjr.20210995
M3 - Article
C2 - 35195444
SN - 0007-1285
VL - 95
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 1134
M1 - A12
ER -