International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function

Nicholas M. Barnes; Gerard P. Ahern; Carine Becamel; Joël Bockaert; Michael Camilleri; Severine Chaumont-Dubel; Sylvie Claeysen; Kathryn A. Cunningham; Kevin C. Fone; Michael Gershon; Giuseppe Di Giovanni; Nathalie M. Goodfellow; Adam L. Halberstadt; Rachel M. Hartley; Ghérici Hassaine; Katharine Herrick-Davis; Ruud Hovius; Enza Lacivita; Evelyn K. Lambe; Marcello Leopoldo; Finn Olav Levy; Sarah C.R. Lummis; Philippe Marin; Luc Maroteaux; Andrew C. McCreary; David L. Nelson; John F. Neumaier; Adrian Newman-Tancredi; Hugues Nury; Alexander Roberts; Bryan L. Roth; Anne Roumier; Gareth J. Sanger; Milt Teitler; Trevor Sharp; Carlos M. Villalón; Horst Vogel; Stephanie W. Watts; Daniel Hoyer

doi:10.1124/PR.118.015552

International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function

Nicholas M. Barnes^*
, Gerard P. Ahern
, Carine Becamel
, Joël Bockaert
, Michael Camilleri
, Severine Chaumont-Dubel
, Sylvie Claeysen
, Kathryn A. Cunningham
, Kevin C. Fone
, Michael Gershon
, Giuseppe Di Giovanni
, Nathalie M. Goodfellow
, Adam L. Halberstadt
, Rachel M. Hartley
, Ghérici Hassaine
, Katharine Herrick-Davis
, Ruud Hovius
, Enza Lacivita
, Evelyn K. Lambe
, Marcello Leopoldo

Finn Olav Levy, Sarah C.R. Lummis, Philippe Marin, Luc Maroteaux, Andrew C. McCreary, David L. Nelson, John F. Neumaier, Adrian Newman-Tancredi, Hugues Nury, Alexander Roberts, Bryan L. Roth, Anne Roumier, Gareth J. Sanger, Milt Teitler, Trevor Sharp, Carlos M. Villalón, Horst Vogel, Stephanie W. Watts, Daniel Hoyer

^*Corresponding author for this work

Pharmacy

Research output: Contribution to journal › Review article › peer-review

Abstract

5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors.

Original language	English
Pages (from-to)	310-520
Number of pages	211
Journal	Pharmacological Reviews
Volume	73
Issue number	1
DOIs	https://doi.org/10.1124/PR.118.015552
Publication status	Published - 2 Jan 2021

Bibliographical note

Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc.

This is an IUPHAR Nomenclature Report.

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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Barnes, N. M., Ahern, G. P., Becamel, C., Bockaert, J., Camilleri, M., Chaumont-Dubel, S., Claeysen, S., Cunningham, K. A., Fone, K. C., Gershon, M., Di Giovanni, G., Goodfellow, N. M., Halberstadt, A. L., Hartley, R. M., Hassaine, G., Herrick-Davis, K., Hovius, R., Lacivita, E., Lambe, E. K., ... Hoyer, D. (2021). International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function. Pharmacological Reviews, 73(1), 310-520. https://doi.org/10.1124/PR.118.015552

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title = "International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function",

abstract = "5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors.",

author = "Barnes, \{Nicholas M.\} and Ahern, \{Gerard P.\} and Carine Becamel and Jo{\"e}l Bockaert and Michael Camilleri and Severine Chaumont-Dubel and Sylvie Claeysen and Cunningham, \{Kathryn A.\} and Fone, \{Kevin C.\} and Michael Gershon and \{Di Giovanni\}, Giuseppe and Goodfellow, \{Nathalie M.\} and Halberstadt, \{Adam L.\} and Hartley, \{Rachel M.\} and Gh{\'e}rici Hassaine and Katharine Herrick-Davis and Ruud Hovius and Enza Lacivita and Lambe, \{Evelyn K.\} and Marcello Leopoldo and Levy, \{Finn Olav\} and Lummis, \{Sarah C.R.\} and Philippe Marin and Luc Maroteaux and McCreary, \{Andrew C.\} and Nelson, \{David L.\} and Neumaier, \{John F.\} and Adrian Newman-Tancredi and Hugues Nury and Alexander Roberts and Roth, \{Bryan L.\} and Anne Roumier and Sanger, \{Gareth J.\} and Milt Teitler and Trevor Sharp and Villal{\'o}n, \{Carlos M.\} and Horst Vogel and Watts, \{Stephanie W.\} and Daniel Hoyer",

note = "Copyright {\textcopyright} 2020 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. This is an IUPHAR Nomenclature Report.",

year = "2021",

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Barnes, NM, Ahern, GP, Becamel, C, Bockaert, J, Camilleri, M, Chaumont-Dubel, S, Claeysen, S, Cunningham, KA, Fone, KC, Gershon, M, Di Giovanni, G, Goodfellow, NM, Halberstadt, AL, Hartley, RM, Hassaine, G, Herrick-Davis, K, Hovius, R, Lacivita, E, Lambe, EK, Leopoldo, M, Levy, FO, Lummis, SCR, Marin, P, Maroteaux, L, McCreary, AC, Nelson, DL, Neumaier, JF, Newman-Tancredi, A, Nury, H, Roberts, A, Roth, BL, Roumier, A, Sanger, GJ, Teitler, M, Sharp, T, Villalón, CM, Vogel, H, Watts, SW & Hoyer, D 2021, 'International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function', Pharmacological Reviews, vol. 73, no. 1, pp. 310-520. https://doi.org/10.1124/PR.118.015552

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AU - Barnes, Nicholas M.

AU - Ahern, Gerard P.

AU - Becamel, Carine

AU - Bockaert, Joël

AU - Camilleri, Michael

AU - Chaumont-Dubel, Severine

AU - Claeysen, Sylvie

AU - Cunningham, Kathryn A.

AU - Fone, Kevin C.

AU - Gershon, Michael

AU - Di Giovanni, Giuseppe

AU - Goodfellow, Nathalie M.

AU - Halberstadt, Adam L.

AU - Hartley, Rachel M.

AU - Hassaine, Ghérici

AU - Herrick-Davis, Katharine

AU - Hovius, Ruud

AU - Lacivita, Enza

AU - Lambe, Evelyn K.

AU - Leopoldo, Marcello

AU - Levy, Finn Olav

AU - Lummis, Sarah C.R.

AU - Marin, Philippe

AU - Maroteaux, Luc

AU - McCreary, Andrew C.

AU - Nelson, David L.

AU - Neumaier, John F.

AU - Newman-Tancredi, Adrian

AU - Nury, Hugues

AU - Roberts, Alexander

AU - Roth, Bryan L.

AU - Roumier, Anne

AU - Sanger, Gareth J.

AU - Teitler, Milt

AU - Sharp, Trevor

AU - Villalón, Carlos M.

AU - Vogel, Horst

AU - Watts, Stephanie W.

AU - Hoyer, Daniel

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AB - 5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors.

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DO - 10.1124/PR.118.015552

M3 - Review article

C2 - 33370241

AN - SCOPUS:85099115764

SN - 0031-6997

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SP - 310

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JO - Pharmacological Reviews

JF - Pharmacological Reviews

IS - 1

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International union of basic and clinical pharmacology. Cx. Classification of receptors for 5-hydroxytryptamine; pharmacology and function

Abstract

Bibliographical note

ASJC Scopus subject areas

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