Interleukin-6, endothelial activation and thrombogenesis in chronic atrial fibrillation

V Roldan, F Marin, Andrew Blann, A Garcia, P Marco, F Sogorb, Gregory Lip

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112 Citations (Scopus)


BACKGROUND: A prothrombotic or hypercoagulable state has been described in AF, which could increase the risk of thromboembolism. As inflammation has been related to thrombogenesis and endothelial activation, we hypothesised that the prothrombotic state in AF (as assessed by an index of thrombogenesis, prothrombin fragment 1+2 [F1+2]) and endothelial activation (soluble E-selectin (sEsel)) could be related to an index of inflammation (interleukin-6 (IL-6)). PATIENTS AND METHODS: We studied 191 consecutive patients (98 male; mean age 72.3+/-9.2 years) with chronic non-rheumatic AF who were not on anticoagulant therapy. Plasma IL-6, sEsel and F1+2 were measured by ELISA. Research indices were compared to 74 controls in sinus rhythm matched for age and sex. In 43 patients with AF, the effects of introducing anticoagulation (INR 2.0-3.0) were also studied. RESULTS: Patients with AF had elevated levels of F1+2 (p
Original languageEnglish
Pages (from-to)1373-1380
Number of pages8
JournalEuropean Heart Journal
Issue number14
Publication statusPublished - 1 Jul 2003


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