Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation

M Finney, GR Guy, RH Michell, J Gordon, B Dugas, KP Rigley, RE Callard

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)

Abstract

We report from three independent centers that, in human tonsillar B lymphocytes, human IL4 switches on a series of second messenger changes, the precise sequence of which constitutes a novel signal transduction cascade. It involves an immediate and transient elevation of inositol 1,4,5-trisphosphate and Ca2+ levels. This is followed several minutes later by a sustained rise in cellular cyclic adenosine monophosphate concentration, the triggering of which involves both the Ca2+ rise and an additional, as yet unidentified, IL4-generated signal. Both the products of the initial inositol lipid hydrolysis and the delayed cyclic adenosine monophosphate accumulation are essential for the later induction of CD23 expression, a major phenotypic change promoted in these cells by IL4. The striking contrast between these findings and those that have been observed for the IL4 triggering of murine B cells is discussed.
Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalEuropean Journal of Immunology
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 1990

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