Interleukin-1 promoter polymorphisms, A deposition and the risk for Alzheimer’s disease

E Green, J Harris, J-C Lambert, D Mann, MC Chartier-Harlin, D St. Clair, H Lemmon, C Iwatsubo, Corinne Lendon

    Research output: Contribution to journalArticle

    Abstract

    Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B-(511) on Abeta(40) load (P <0.05) was detected.
    Original languageEnglish
    Pages (from-to)1566-8
    Number of pages3
    JournalNeurology
    Volume58
    Publication statusPublished - 1 Jan 2002

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