Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook

Graham Van Aggelen; Gerald T Ankley; William S Baldwin; Daniel W Bearden; William H Benson; J Kevin Chipman; Tim W Collette; John A Craft; Nancy D Denslow; Michael R Embry; Francesco Falciani; Stephen G George; Caren C Helbing; Paul F Hoekstra; Taisen Iguchi; Yoshi Kagami; Ioanna Katsiadaki; Peter Kille; Li Liu; Peter G Lord; Terry McIntyre; Anne O'Neill; Heather Osachoff; Ed J Perkins; Eduarda M Santos; Rachel C Skirrow; Jason R Snape; Charles R Tyler; Don Versteeg; Mark R Viant; David C Volz; Timothy Williams; Lorraine Yu

doi:10.1289/ehp.0900985

Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook

Graham Van Aggelen, Gerald T Ankley, William S Baldwin, Daniel W Bearden, William H Benson, J Kevin Chipman, Tim W Collette, John A Craft, Nancy D Denslow, Michael R Embry, Francesco Falciani, Stephen G George, Caren C Helbing, Paul F Hoekstra, Taisen Iguchi, Yoshi Kagami, Ioanna Katsiadaki, Peter Kille, Li Liu, Peter G LordTerry McIntyre, Anne O'Neill, Heather Osachoff, Ed J Perkins, Eduarda M Santos, Rachel C Skirrow, Jason R Snape, Charles R Tyler, Don Versteeg, Mark R Viant, David C Volz, Timothy Williams, Lorraine Yu

Biosciences

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Abstract

BACKGROUND: In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada).

OBJECTIVES: The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets.

DISCUSSION: Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data.

CONCLUSIONS: The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Environmental Health Perspectives
Volume	118
Issue number	1
DOIs	https://doi.org/10.1289/ehp.0900985
Publication status	Published - Jan 2010

Keywords

Animals
Ecotoxicology
Environmental Monitoring
Fishes
International Agencies
Risk Assessment
Toxicogenetics

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10.1289/ehp.0900985

EHP Vancouver PublishedFinal published version, 213 KBLicence: Creative Commons: Attribution (CC BY)

International Consortium on Fish Toxicogenomics
Chipman, K. (Principal Investigator) & Viant, M. (Co-Investigator)
Natural Environment Research Council
10/04/06 → 9/04/09
Project: Research Councils
Identifying and Defining the Bases of Individual and Population Susceptibility and Adaption to Environmental Pollutants in Fish: An Integrated Transcriptomic and Metabolomic Approach
Chipman, K. (Principal Investigator), Falciani, F. (Co-Investigator), Viant, M. (Co-Investigator) & Minchin, S. (Co-Investigator)
Natural Environment Research Council
1/04/05 → 30/11/08
Project: Research Councils

Cite this

Van Aggelen, G., Ankley, G. T., Baldwin, W. S., Bearden, D. W., Benson, W. H., Chipman, J. K., Collette, T. W., Craft, J. A., Denslow, N. D., Embry, M. R., Falciani, F., George, S. G., Helbing, C. C., Hoekstra, P. F., Iguchi, T., Kagami, Y., Katsiadaki, I., Kille, P., Liu, L., ... Yu, L. (2010). Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook. Environmental Health Perspectives, 118(1), 1-5. https://doi.org/10.1289/ehp.0900985

@article{cfe8e3e81d994f9891a70981d0c8a901,

title = "Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook",

abstract = "BACKGROUND: In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada).OBJECTIVES: The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets.DISCUSSION: Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data.CONCLUSIONS: The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.",

keywords = "Animals, Ecotoxicology, Environmental Monitoring, Fishes, International Agencies, Risk Assessment, Toxicogenetics",

author = "{Van Aggelen}, Graham and Ankley, {Gerald T} and Baldwin, {William S} and Bearden, {Daniel W} and Benson, {William H} and Chipman, {J Kevin} and Collette, {Tim W} and Craft, {John A} and Denslow, {Nancy D} and Embry, {Michael R} and Francesco Falciani and George, {Stephen G} and Helbing, {Caren C} and Hoekstra, {Paul F} and Taisen Iguchi and Yoshi Kagami and Ioanna Katsiadaki and Peter Kille and Li Liu and Lord, {Peter G} and Terry McIntyre and Anne O'Neill and Heather Osachoff and Perkins, {Ed J} and Santos, {Eduarda M} and Skirrow, {Rachel C} and Snape, {Jason R} and Tyler, {Charles R} and Don Versteeg and Viant, {Mark R} and Volz, {David C} and Timothy Williams and Lorraine Yu",

year = "2010",

month = jan,

doi = "10.1289/ehp.0900985",

language = "English",

volume = "118",

pages = "1--5",

journal = "Environmental Health Perspectives",

publisher = "National Institute of Environmental Health Sciences",

number = "1",

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Van Aggelen, G, Ankley, GT, Baldwin, WS, Bearden, DW, Benson, WH, Chipman, JK, Collette, TW, Craft, JA, Denslow, ND, Embry, MR, Falciani, F, George, SG, Helbing, CC, Hoekstra, PF, Iguchi, T, Kagami, Y, Katsiadaki, I, Kille, P, Liu, L, Lord, PG, McIntyre, T, O'Neill, A, Osachoff, H, Perkins, EJ, Santos, EM, Skirrow, RC, Snape, JR, Tyler, CR, Versteeg, D, Viant, MR, Volz, DC, Williams, T & Yu, L 2010, 'Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook', Environmental Health Perspectives, vol. 118, no. 1, pp. 1-5. https://doi.org/10.1289/ehp.0900985

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T1 - Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring

T2 - hurdles, achievements, and future outlook

AU - Van Aggelen, Graham

AU - Ankley, Gerald T

AU - Baldwin, William S

AU - Bearden, Daniel W

AU - Benson, William H

AU - Chipman, J Kevin

AU - Collette, Tim W

AU - Craft, John A

AU - Denslow, Nancy D

AU - Embry, Michael R

AU - Falciani, Francesco

AU - George, Stephen G

AU - Helbing, Caren C

AU - Hoekstra, Paul F

AU - Iguchi, Taisen

AU - Kagami, Yoshi

AU - Katsiadaki, Ioanna

AU - Kille, Peter

AU - Liu, Li

AU - Lord, Peter G

AU - McIntyre, Terry

AU - O'Neill, Anne

AU - Osachoff, Heather

AU - Perkins, Ed J

AU - Santos, Eduarda M

AU - Skirrow, Rachel C

AU - Snape, Jason R

AU - Tyler, Charles R

AU - Versteeg, Don

AU - Viant, Mark R

AU - Volz, David C

AU - Williams, Timothy

AU - Yu, Lorraine

PY - 2010/1

Y1 - 2010/1

N2 - BACKGROUND: In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada).OBJECTIVES: The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets.DISCUSSION: Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data.CONCLUSIONS: The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.

AB - BACKGROUND: In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada).OBJECTIVES: The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets.DISCUSSION: Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data.CONCLUSIONS: The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.

KW - Animals

KW - Ecotoxicology

KW - Environmental Monitoring

KW - Fishes

KW - International Agencies

KW - Risk Assessment

KW - Toxicogenetics

U2 - 10.1289/ehp.0900985

DO - 10.1289/ehp.0900985

M3 - Article

C2 - 20056575

VL - 118

SP - 1

EP - 5

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 1

ER -

Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook

Abstract

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Projects

International Consortium on Fish Toxicogenomics

Identifying and Defining the Bases of Individual and Population Susceptibility and Adaption to Environmental Pollutants in Fish: An Integrated Transcriptomic and Metabolomic Approach

Cite this