Integrating genetic risk assessment for multi-factorial conditions into primary care

Alison Metcalfe, Sue Wilson, Deborah McCahon, Helen Sleightholme, Paramjit Gill, T Cole

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
158 Downloads (Pure)


The genetic basis of many common, multi-factorial conditions is increasingly being understood but use of the knowledge created, raises major dilemmas for primary care. Identification of individuals that may be genetically predisposed to serious medical conditions provides the opportunity to offer screening or prophylactic treatment, for early detection or prevention and delay in disease onset in many complex conditions. We describe a new pilot service development to introduce genetic risk assessment for a wide range of conditions to primary care, and discuss the findings from its evaluation. The evaluation highlighted the issues about the incorporation of genetic risk assessment in primary care. The results of the evaluation along with findings from other studies, juxtaposed with the implications of developments in genetics suggest that changes are required to accommodate the integration of genetic risk assessment into primary care clinical practice. We discuss what these changes are, the benefits and drawbacks, and whether primary care can and is ready to make the changes required, further shifting the focus from disease treatment to disease prevention.
Original languageEnglish
Pages (from-to)200-209
Number of pages10
JournalPrimary Health Care Research & Development 2009
Issue number03
Publication statusPublished - 1 Jul 2009


  • family
  • genetics
  • prevention
  • primary care
  • risk
  • screening


Dive into the research topics of 'Integrating genetic risk assessment for multi-factorial conditions into primary care'. Together they form a unique fingerprint.

Cite this