Abstract
At the opening of the 1980s, two camps vigorously contested whether receptor-stimulated inositol lipid hydrolysis was a transmembrane signalling reaction that brought about an elevation of cytosolic [Ca2+] or simply a frequent, but unexplained, response of many stimulated cells to a stimulated elevation of cytosolic [Ca2+]. Since 1984, this discussion has been replaced by intensive work that is well on the way to providing a detailed description of the complex set of signalling pathways initiated by phosphatidylinositol 4,5-biphosphate hydrolysis to form the second messengers inositol 1,4,5-triphosphate and 1,2-diacylglycerol. In addition, it has been realized that cells closely regulate their levels both of a novel family of 3-phosphorylated inositol lipids and of a large number of water-soluble inositol polyphosphates; the definition of the functions of these molecules will be a job for the 1990s.
Original language | English |
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Pages (from-to) | 274-276 |
Number of pages | 3 |
Journal | Trends in Biochemical Sciences |
Volume | 17 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Jan 1992 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology