Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB). 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites.

Jonathan Bilmen, Laura Peake, Rita Godfrey, Oliver Smart, Francesco Michelangeli

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Medicine & Life Sciences

Chemistry