Increased response to visual feedback of drug-induced dyskinetic movements in advanced Parkinson's disease

Xuguang Liu, Robert Österbauer, Tipu Z. Aziz, R. Christopher Miall, John F. Stein

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

To investigate the response to visual feedback of involuntary movements which have a frequency composition similar to cerebellar tremor but are not caused by cerebellar damage, we have tested six advanced Parkinson's disease (PD) patients with drug-induced dyskinetic movements using visually guided wrist tracking tasks. Tracking performance was assessed under three visual conditions: (1) both guiding target and movement cursor were displayed continuously; (2) the target display was turned off for the second half of each trial; or (3) the cursor display, but not the target, was turned off for the second half of each trial. The response to visual feedback of drug-induced dyskinetic movements at 1-5 Hz in these advanced PD patients were significantly increased than in normal controls. This suggests that increased response to visual feedback might be a common feature of low frequency involuntary movements and not directly caused by cerebellar damages.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalNeuroscience Letters
Volume304
Issue number1-2
DOIs
Publication statusPublished - 18 May 2001

Keywords

  • Drug-induced dyskinesia
  • Parkinson's disease
  • Tracking
  • Visual feedback

ASJC Scopus subject areas

  • Neuroscience(all)

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