Increased levels of soluble P-selectin correlate with iron overload in sickle cell disease

Andrew Blann; SS Marwah; AJ Cobley; D Bareford

Increased levels of soluble P-selectin correlate with iron overload in sickle cell disease

Andrew Blann, SS Marwah, AJ Cobley, D Bareford

Birmingham Medical School

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1 Citation (Scopus)

Abstract

Homozygous sickle cell disease (SCD) is characterised by increased soluble P-selectin (sP-selectin), suggesting increased platelet activation, and high non-transferrin-bound iron (NTBI), reflecting iron overload, possibly due to blood transfusion. Hypothesising a relationship between these processes, we measured both markers in 40 SCD patients and 40 age/gender/race-matched controls, finding increased levels of each marker in the patients (both P

Original language	English
Pages (from-to)	124-6
Number of pages	3
Journal	British journal of biomedical science
Volume	64
Issue number	3
Publication status	Published - 1 Jan 2007

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title = "Increased levels of soluble P-selectin correlate with iron overload in sickle cell disease",

abstract = "Homozygous sickle cell disease (SCD) is characterised by increased soluble P-selectin (sP-selectin), suggesting increased platelet activation, and high non-transferrin-bound iron (NTBI), reflecting iron overload, possibly due to blood transfusion. Hypothesising a relationship between these processes, we measured both markers in 40 SCD patients and 40 age/gender/race-matched controls, finding increased levels of each marker in the patients (both P",

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AU - Marwah, SS

AU - Cobley, AJ

AU - Bareford, D

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N2 - Homozygous sickle cell disease (SCD) is characterised by increased soluble P-selectin (sP-selectin), suggesting increased platelet activation, and high non-transferrin-bound iron (NTBI), reflecting iron overload, possibly due to blood transfusion. Hypothesising a relationship between these processes, we measured both markers in 40 SCD patients and 40 age/gender/race-matched controls, finding increased levels of each marker in the patients (both P

AB - Homozygous sickle cell disease (SCD) is characterised by increased soluble P-selectin (sP-selectin), suggesting increased platelet activation, and high non-transferrin-bound iron (NTBI), reflecting iron overload, possibly due to blood transfusion. Hypothesising a relationship between these processes, we measured both markers in 40 SCD patients and 40 age/gender/race-matched controls, finding increased levels of each marker in the patients (both P

M3 - Article

C2 - 17910282

VL - 64

SP - 124

EP - 126

JO - British journal of biomedical science

JF - British journal of biomedical science

IS - 3

ER -

Increased levels of soluble P-selectin correlate with iron overload in sickle cell disease

Abstract

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