Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen

R Thimme, V Appay, M Koschella, E Panther, E Roth, Andrew Hislop, Alan Rickinson, SL Rowland-Jones, HE Blum, H Pircher

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111 Citations (Scopus)

Abstract

The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus). Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation.
Original languageEnglish
Pages (from-to)12112-12116
Number of pages5
JournalJournal of virology
Volume79
DOIs
Publication statusPublished - 15 Sep 2005

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