Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen

R Thimme; V Appay; M Koschella; E Panther; E Roth; Andrew Hislop; Alan Rickinson; SL Rowland-Jones; HE Blum; H Pircher

doi:10.1128/JVI.79.18.12112-12116.2005

Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen

R Thimme, V Appay, M Koschella, E Panther, E Roth, Andrew Hislop, Alan Rickinson, SL Rowland-Jones, HE Blum, H Pircher

Cancer and Genomic Sciences

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Abstract

The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus). Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation.

Original language	English
Pages (from-to)	12112-12116
Number of pages	5
Journal	Journal of virology
Volume	79
DOIs	https://doi.org/10.1128/JVI.79.18.12112-12116.2005
Publication status	Published - 15 Sept 2005

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title = "Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen",

abstract = "The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus). Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation.",

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AU - Thimme, R

AU - Appay, V

AU - Koschella, M

AU - Panther, E

AU - Roth, E

AU - Hislop, Andrew

AU - Rickinson, Alan

AU - Rowland-Jones, SL

AU - Blum, HE

AU - Pircher, H

PY - 2005/9/15

Y1 - 2005/9/15

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AB - The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus). Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation.

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DO - 10.1128/JVI.79.18.12112-12116.2005

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Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen

Abstract

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