Increased circulating endothelial cells in acute heart failure: Comparison with von Willebrand factor and soluble E-selectin

Aun Chong; Gregory Lip; B Freestone; Andrew Blann

doi:10.1016/j.ejheart.2005.06.010

Increased circulating endothelial cells in acute heart failure: Comparison with von Willebrand factor and soluble E-selectin

Aun Chong, Gregory Lip, B Freestone, Andrew Blann

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Abstract

Back round: Circulating endothelial cells (CECs) in the peripheral blood, probably representing the most direct evidence of endothelial cell g damage, are increased in myocardial infarction, unstable angina and critical limb ischaemia. As chronic heart failure is also associated with endothelial abnormalities, we hypothesised that CECs are raised in acute heart failure and that they would correlate with plasma indices of endothelial perturbation, that is, von Willebrand factor (vWf) and soluble E-selectin. Methods: We studied 30 patients with acute heart failure (venesected within 24 It of emergency hospital admission), 30 patients with chronic stable heart failure (venesected as out-patients, all patients in sinus rhythm with ejection fraction

Original language	English
Pages (from-to)	167-172
Number of pages	6
Journal	European Journal of Heart Failure
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/j.ejheart.2005.06.010
Publication status	Published - 1 Mar 2006

Keywords

von Willebrand factor
endothelium
soluble E-selectin
heart failure
circulating endothelial cells

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10.1016/j.ejheart.2005.06.010

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title = "Increased circulating endothelial cells in acute heart failure: Comparison with von Willebrand factor and soluble E-selectin",

abstract = "Back round: Circulating endothelial cells (CECs) in the peripheral blood, probably representing the most direct evidence of endothelial cell g damage, are increased in myocardial infarction, unstable angina and critical limb ischaemia. As chronic heart failure is also associated with endothelial abnormalities, we hypothesised that CECs are raised in acute heart failure and that they would correlate with plasma indices of endothelial perturbation, that is, von Willebrand factor (vWf) and soluble E-selectin. Methods: We studied 30 patients with acute heart failure (venesected within 24 It of emergency hospital admission), 30 patients with chronic stable heart failure (venesected as out-patients, all patients in sinus rhythm with ejection fraction ",

keywords = "von Willebrand factor, endothelium, soluble E-selectin, heart failure, circulating endothelial cells",

author = "Aun Chong and Gregory Lip and B Freestone and Andrew Blann",

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T1 - Increased circulating endothelial cells in acute heart failure: Comparison with von Willebrand factor and soluble E-selectin

AU - Chong, Aun

AU - Lip, Gregory

AU - Freestone, B

AU - Blann, Andrew

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Back round: Circulating endothelial cells (CECs) in the peripheral blood, probably representing the most direct evidence of endothelial cell g damage, are increased in myocardial infarction, unstable angina and critical limb ischaemia. As chronic heart failure is also associated with endothelial abnormalities, we hypothesised that CECs are raised in acute heart failure and that they would correlate with plasma indices of endothelial perturbation, that is, von Willebrand factor (vWf) and soluble E-selectin. Methods: We studied 30 patients with acute heart failure (venesected within 24 It of emergency hospital admission), 30 patients with chronic stable heart failure (venesected as out-patients, all patients in sinus rhythm with ejection fraction

AB - Back round: Circulating endothelial cells (CECs) in the peripheral blood, probably representing the most direct evidence of endothelial cell g damage, are increased in myocardial infarction, unstable angina and critical limb ischaemia. As chronic heart failure is also associated with endothelial abnormalities, we hypothesised that CECs are raised in acute heart failure and that they would correlate with plasma indices of endothelial perturbation, that is, von Willebrand factor (vWf) and soluble E-selectin. Methods: We studied 30 patients with acute heart failure (venesected within 24 It of emergency hospital admission), 30 patients with chronic stable heart failure (venesected as out-patients, all patients in sinus rhythm with ejection fraction

KW - von Willebrand factor

KW - endothelium

KW - soluble E-selectin

KW - heart failure

KW - circulating endothelial cells

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DO - 10.1016/j.ejheart.2005.06.010

M3 - Article

C2 - 16185922

SN - 1879-0844

VL - 8

SP - 167

EP - 172

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

IS - 2

ER -

Increased circulating endothelial cells in acute heart failure: Comparison with von Willebrand factor and soluble E-selectin

Abstract

Keywords

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