TY - JOUR
T1 - Increase in systemic vascular resistance during acute mental stress in patients with rheumatoid arthritis with high-grade systemic inflammation
AU - Veldhuijzen van Zanten, Joachimina
AU - Kitas, George
AU - Carroll, Douglas
AU - Ring, Christopher
PY - 2008
Y1 - 2008
N2 - Patients with rheumatoid arthritis are at increased risk for myocardial infarction. It has been hypothesized that mental stress-induced cardiovascular reactions may play a role in the triggering of myocardial infarction. Cardiovascular activity was measured during rest, stress, and recovery in rheumatoid arthritis patients with high systemic inflammation (C-reactive protein > 8 mg/l), rheumatoid arthritis patients with low systemic inflammation (C-reactive protein <8 mg/l), and osteoarthritis patients. Systemic vascular resistance increased only in rheumatoid arthritis patients with high systemic inflammation. Heart rate and mean arterial pressure increased during the stress task in all groups. Thus, acute cardiovascular events in rheumatoid arthritis patients may be related to stress-induced increases in systemic vascular resistance, particularly in patients with high levels of systemic inflammation. (C) 2007 Elsevier B.V. All rights reserved.
AB - Patients with rheumatoid arthritis are at increased risk for myocardial infarction. It has been hypothesized that mental stress-induced cardiovascular reactions may play a role in the triggering of myocardial infarction. Cardiovascular activity was measured during rest, stress, and recovery in rheumatoid arthritis patients with high systemic inflammation (C-reactive protein > 8 mg/l), rheumatoid arthritis patients with low systemic inflammation (C-reactive protein <8 mg/l), and osteoarthritis patients. Systemic vascular resistance increased only in rheumatoid arthritis patients with high systemic inflammation. Heart rate and mean arterial pressure increased during the stress task in all groups. Thus, acute cardiovascular events in rheumatoid arthritis patients may be related to stress-induced increases in systemic vascular resistance, particularly in patients with high levels of systemic inflammation. (C) 2007 Elsevier B.V. All rights reserved.
KW - systemic vascular resistance
KW - inflammation
KW - rheumatoid arthritis
KW - acute stress
U2 - 10.1016/j.biopsycho.2007.09.002
DO - 10.1016/j.biopsycho.2007.09.002
M3 - Article
C2 - 17949887
SN - 0301-0511
VL - 77
SP - 106
EP - 110
JO - Biological Psychology
JF - Biological Psychology
IS - 1
ER -