Incorporating oral bioaccessibility into human health risk assessment due to potentially toxic elements in extractive waste and contaminated soils from an abandoned mine site

Neha Mehta; Sabrina Cipullo; Tatiana Cocerva; Frederic Coulon; Giovanna Antonella Dino; Franco Ajmone-Marsan; Elio Padoan; Siobhan Fiona Cox; Mark R. Cave; Domenico Antonio De Luca

doi:10.1016/j.chemosphere.2020.126927

Incorporating oral bioaccessibility into human health risk assessment due to potentially toxic elements in extractive waste and contaminated soils from an abandoned mine site

Neha Mehta^*, Sabrina Cipullo, Tatiana Cocerva, Frederic Coulon, Giovanna Antonella Dino, Franco Ajmone-Marsan, Elio Padoan, Siobhan Fiona Cox, Mark R. Cave, Domenico Antonio De Luca

^*Corresponding author for this work

Chemical Engineering

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Abstract

The waste rock, tailings and soil around an abandoned mine site in Gorno (northwest Italy) contain elevated concentrations of potentially toxic elements (PTE) exceeding the permissible limits for residential uses. Specifically, the maximum concentrations of As, Cd, Pb, and Zn were 107 mg/kg, 340 mg/kg, 1064 mg/kg, and 148 433 mg/kg, respectively. A site-specific human health risk assessment (HHRA) was conducted for residential and recreational exposure scenarios, using an approach based on Risk Based Corrective Action (RBCA) method, refined by incorporating oral bioaccessibility data.

Oral bioaccessibility analyses were performed by simulating the human digestion process in vitro (Unified BARGE Method). Detailed analysis of oral bioaccessible fraction (BAF i.e. ratio of bioaccessible concentrations to total concentrations on 1) for 50% of the samples, indicating potential human health risks. This study provides information for site-specific risk assessments and planning future research.

Original language	English
Article number	126927
Pages (from-to)	1-14
Number of pages	14
Journal	Chemosphere
Volume	255
DOIs	https://doi.org/10.1016/j.chemosphere.2020.126927
Publication status	Published - Sept 2020

Keywords

Abandoned mine site
Bioaccessibility
Potentially toxic elements
Risk assessment
Solid phase distribution
Triassic western southern alps (Italy)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Gorno bioaccessibility_Mehta et al 2020Accepted author manuscript, 2.46 MBLicence: Other (please provide link to licence statement

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Mehta, N., Cipullo, S., Cocerva, T., Coulon, F., Dino, G. A., Ajmone-Marsan, F., Padoan, E., Cox, S. F., Cave, M. R., & De Luca, D. A. (2020). Incorporating oral bioaccessibility into human health risk assessment due to potentially toxic elements in extractive waste and contaminated soils from an abandoned mine site. Chemosphere, 255, 1-14. Article 126927. https://doi.org/10.1016/j.chemosphere.2020.126927

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title = "Incorporating oral bioaccessibility into human health risk assessment due to potentially toxic elements in extractive waste and contaminated soils from an abandoned mine site",

abstract = "The waste rock, tailings and soil around an abandoned mine site in Gorno (northwest Italy) contain elevated concentrations of potentially toxic elements (PTE) exceeding the permissible limits for residential uses. Specifically, the maximum concentrations of As, Cd, Pb, and Zn were 107 mg/kg, 340 mg/kg, 1064 mg/kg, and 148 433 mg/kg, respectively. A site-specific human health risk assessment (HHRA) was conducted for residential and recreational exposure scenarios, using an approach based on Risk Based Corrective Action (RBCA) method, refined by incorporating oral bioaccessibility data.Oral bioaccessibility analyses were performed by simulating the human digestion process in vitro (Unified BARGE Method). Detailed analysis of oral bioaccessible fraction (BAF i.e. ratio of bioaccessible concentrations to total concentrations on 1) for 50% of the samples, indicating potential human health risks. This study provides information for site-specific risk assessments and planning future research.",

keywords = "Abandoned mine site, Bioaccessibility, Potentially toxic elements, Risk assessment, Solid phase distribution, Triassic western southern alps (Italy)",

author = "Neha Mehta and Sabrina Cipullo and Tatiana Cocerva and Frederic Coulon and Dino, {Giovanna Antonella} and Franco Ajmone-Marsan and Elio Padoan and Cox, {Siobhan Fiona} and Cave, {Mark R.} and {De Luca}, {Domenico Antonio}",

year = "2020",

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doi = "10.1016/j.chemosphere.2020.126927",

language = "English",

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Mehta, N, Cipullo, S, Cocerva, T, Coulon, F, Dino, GA, Ajmone-Marsan, F, Padoan, E, Cox, SF, Cave, MR & De Luca, DA 2020, 'Incorporating oral bioaccessibility into human health risk assessment due to potentially toxic elements in extractive waste and contaminated soils from an abandoned mine site', Chemosphere, vol. 255, 126927, pp. 1-14. https://doi.org/10.1016/j.chemosphere.2020.126927

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AU - Mehta, Neha

AU - Cipullo, Sabrina

AU - Cocerva, Tatiana

AU - Coulon, Frederic

AU - Dino, Giovanna Antonella

AU - Ajmone-Marsan, Franco

AU - Padoan, Elio

AU - Cox, Siobhan Fiona

AU - Cave, Mark R.

AU - De Luca, Domenico Antonio

PY - 2020/9

Y1 - 2020/9

N2 - The waste rock, tailings and soil around an abandoned mine site in Gorno (northwest Italy) contain elevated concentrations of potentially toxic elements (PTE) exceeding the permissible limits for residential uses. Specifically, the maximum concentrations of As, Cd, Pb, and Zn were 107 mg/kg, 340 mg/kg, 1064 mg/kg, and 148 433 mg/kg, respectively. A site-specific human health risk assessment (HHRA) was conducted for residential and recreational exposure scenarios, using an approach based on Risk Based Corrective Action (RBCA) method, refined by incorporating oral bioaccessibility data.Oral bioaccessibility analyses were performed by simulating the human digestion process in vitro (Unified BARGE Method). Detailed analysis of oral bioaccessible fraction (BAF i.e. ratio of bioaccessible concentrations to total concentrations on 1) for 50% of the samples, indicating potential human health risks. This study provides information for site-specific risk assessments and planning future research.

AB - The waste rock, tailings and soil around an abandoned mine site in Gorno (northwest Italy) contain elevated concentrations of potentially toxic elements (PTE) exceeding the permissible limits for residential uses. Specifically, the maximum concentrations of As, Cd, Pb, and Zn were 107 mg/kg, 340 mg/kg, 1064 mg/kg, and 148 433 mg/kg, respectively. A site-specific human health risk assessment (HHRA) was conducted for residential and recreational exposure scenarios, using an approach based on Risk Based Corrective Action (RBCA) method, refined by incorporating oral bioaccessibility data.Oral bioaccessibility analyses were performed by simulating the human digestion process in vitro (Unified BARGE Method). Detailed analysis of oral bioaccessible fraction (BAF i.e. ratio of bioaccessible concentrations to total concentrations on 1) for 50% of the samples, indicating potential human health risks. This study provides information for site-specific risk assessments and planning future research.

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KW - Bioaccessibility

KW - Potentially toxic elements

KW - Risk assessment

KW - Solid phase distribution

KW - Triassic western southern alps (Italy)

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U2 - 10.1016/j.chemosphere.2020.126927

DO - 10.1016/j.chemosphere.2020.126927

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JO - Chemosphere

JF - Chemosphere

M1 - 126927

ER -

Incorporating oral bioaccessibility into human health risk assessment due to potentially toxic elements in extractive waste and contaminated soils from an abandoned mine site

Abstract

Keywords

UN SDGs

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