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Haematopoietic stem and progenitor cells (HSPCs) sustain haematopoiesis by generating precise numbers of mature blood cells throughout the lifetime of an individual. In vertebrates, HSPCs arise during embryonic development from a specialised endothelial cell population, the haemogenic endothelium (HE). Signalling by the Transforming Growth Factor β (TGFβ) pathway is key to regulate haematopoiesis in the adult bone marrow, but evidence for a role in the formation of HSPCs has only recently started to emerge. In this review, we examine recent work in various model systems that demonstrate a key role for TGFβ signalling in HSPC emergence from the HE. The current evidence underpins two seemingly contradictory views of TGFβ function: as a negative regulator of HSPCs by limiting haematopoietic output from HE, and as a positive regulator, by programming the HE towards the haematopoietic fate. Understanding how to modulate the requirement for TGFβ signalling in HSC emergence may have critical implications for the generation of these cells in vitro for therapeutic use.
Bibliographical noteFunding Information:
R.T. is a recipient of BP2016(00021) and BP/MSCA 2018(00034) fellowship programs from the Generalitat de Catalunya/Marie Skłodowska-Curie Actions. R.M. is funded by the University of Birmingham and supported by Cancer Research UK [C17422/A25154].
R.T. is a recipient of BP2016(00021) and BP/MSCA 2018(00034) fellowship programs from the Generalitat de Catalunya/Marie Sk?odowska-Curie Actions. R.M. is funded by the University of Birmingham and supported by Cancer Research UK [C17422/A25154].
© 2022 The Author(s)
- endothelial to haematopoietic transition
- haemogenic endothelium
- mouse models
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- 3 Finished
1/02/19 → 30/09/19
1/06/18 → 31/03/20
1/05/18 → 31/12/18