In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg/Th17 cells and of in situ infiltrated inflammatory monocytes in the onset of gouty inflammation

Federica Raucci, Asif J Iqbal, Anella Saviano, Gian Marco Casillo, Marina Russo, Danielle Lezama, Nicola Mascolo, Francesco Maione

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
133 Downloads (Pure)

Abstract

The data supplied in this work are related to the research article entitled "IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation" [1]. This data article presents the results of the gating strategy applied to identify Treg population in peripheral blood of mice injected with MSU crystals and MSU crystals + interleukin-17 antibody (IL-17Ab). Lastly, this article provides in-depth immunophenotyping data relating to all specific and isotype control antibodies used in the phenotypical characterization of circulating Treg (defined as CD4+CD25+Foxp3+), Th17 (defined as CD4+IL-17+) cells and joint-infiltrated (in situ) inflammatory monocytes (defined as B220-GR1highF480highCD115+).

Original languageEnglish
Article number104381
Number of pages7
JournalData in Brief
Volume25
DOIs
Publication statusPublished - 12 Aug 2019

Keywords

  • Gout
  • IL-17A
  • Monocytes
  • Monosodium urate crystals
  • Neutralizing antibody
  • Th17
  • Treg

ASJC Scopus subject areas

  • General

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