In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg/Th17 cells and of in situ infiltrated inflammatory monocytes in the onset of gouty inflammation

Federica Raucci; Asif J Iqbal; Anella Saviano; Gian Marco Casillo; Marina Russo; Danielle Lezama; Nicola Mascolo; Francesco Maione

doi:10.1016/j.dib.2019.104381

In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg/Th17 cells and of in situ infiltrated inflammatory monocytes in the onset of gouty inflammation

Federica Raucci, Asif J Iqbal, Anella Saviano, Gian Marco Casillo, Marina Russo, Danielle Lezama, Nicola Mascolo, Francesco Maione

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Abstract

The data supplied in this work are related to the research article entitled "IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation" [1]. This data article presents the results of the gating strategy applied to identify Treg population in peripheral blood of mice injected with MSU crystals and MSU crystals + interleukin-17 antibody (IL-17Ab). Lastly, this article provides in-depth immunophenotyping data relating to all specific and isotype control antibodies used in the phenotypical characterization of circulating Treg (defined as CD4⁺CD25⁺Foxp3⁺), Th17 (defined as CD4⁺IL^-17⁺) cells and joint-infiltrated (in situ) inflammatory monocytes (defined as B220^-GR1^highF480^highCD115⁺).

Original language	English
Article number	104381
Number of pages	7
Journal	Data in Brief
Volume	25
DOIs	https://doi.org/10.1016/j.dib.2019.104381
Publication status	Published - 12 Aug 2019

Keywords

Gout
IL-17A
Monocytes
Monosodium urate crystals
Neutralizing antibody
Th17
Treg

ASJC Scopus subject areas

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10.1016/j.dib.2019.104381Licence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

Raucci_et_al_In_depth_immunophenotyping_data_relating_to_IL_17Ab_modulation_of_circulating_Treg/Th17_cells_Data_in_Brief_2019
Checked for eligibility: 17/09/2019
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@article{ef811c7c70fd4a9cbf0221f1e58ba183,

title = "In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg/Th17 cells and of in situ infiltrated inflammatory monocytes in the onset of gouty inflammation",

abstract = "The data supplied in this work are related to the research article entitled {"}IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation{"} [1]. This data article presents the results of the gating strategy applied to identify Treg population in peripheral blood of mice injected with MSU crystals and MSU crystals + interleukin-17 antibody (IL-17Ab). Lastly, this article provides in-depth immunophenotyping data relating to all specific and isotype control antibodies used in the phenotypical characterization of circulating Treg (defined as CD4+CD25+Foxp3+), Th17 (defined as CD4+IL-17+) cells and joint-infiltrated (in situ) inflammatory monocytes (defined as B220-GR1highF480highCD115+).",

keywords = "Gout, IL-17A, Monocytes, Monosodium urate crystals, Neutralizing antibody, Th17, Treg",

author = "Federica Raucci and Iqbal, {Asif J} and Anella Saviano and Casillo, {Gian Marco} and Marina Russo and Danielle Lezama and Nicola Mascolo and Francesco Maione",

year = "2019",

month = aug,

day = "12",

doi = "10.1016/j.dib.2019.104381",

language = "English",

volume = "25",

journal = "Data in Brief",

issn = "2352-3409",

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TY - JOUR

T1 - In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg/Th17 cells and of in situ infiltrated inflammatory monocytes in the onset of gouty inflammation

AU - Raucci, Federica

AU - Iqbal, Asif J

AU - Saviano, Anella

AU - Casillo, Gian Marco

AU - Russo, Marina

AU - Lezama, Danielle

AU - Mascolo, Nicola

AU - Maione, Francesco

PY - 2019/8/12

Y1 - 2019/8/12

N2 - The data supplied in this work are related to the research article entitled "IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation" [1]. This data article presents the results of the gating strategy applied to identify Treg population in peripheral blood of mice injected with MSU crystals and MSU crystals + interleukin-17 antibody (IL-17Ab). Lastly, this article provides in-depth immunophenotyping data relating to all specific and isotype control antibodies used in the phenotypical characterization of circulating Treg (defined as CD4+CD25+Foxp3+), Th17 (defined as CD4+IL-17+) cells and joint-infiltrated (in situ) inflammatory monocytes (defined as B220-GR1highF480highCD115+).

AB - The data supplied in this work are related to the research article entitled "IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation" [1]. This data article presents the results of the gating strategy applied to identify Treg population in peripheral blood of mice injected with MSU crystals and MSU crystals + interleukin-17 antibody (IL-17Ab). Lastly, this article provides in-depth immunophenotyping data relating to all specific and isotype control antibodies used in the phenotypical characterization of circulating Treg (defined as CD4+CD25+Foxp3+), Th17 (defined as CD4+IL-17+) cells and joint-infiltrated (in situ) inflammatory monocytes (defined as B220-GR1highF480highCD115+).

KW - Gout

KW - IL-17A

KW - Monocytes

KW - Monosodium urate crystals

KW - Neutralizing antibody

KW - Th17

KW - Treg

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U2 - 10.1016/j.dib.2019.104381

DO - 10.1016/j.dib.2019.104381

M3 - Article

C2 - 31489355

SN - 2352-3409

VL - 25

JO - Data in Brief

JF - Data in Brief

M1 - 104381

ER -

In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg/Th17 cells and of in situ infiltrated inflammatory monocytes in the onset of gouty inflammation

Abstract

Keywords

ASJC Scopus subject areas

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