Improving mechanical properties of crystalline solids by cocrystal formation: new compressible forms of paracetamol

Shyam Karki; Tomislav Friščić; László Fabián; Peter R. Laity; Graeme M. Day; William Jones

doi:10.1002/adma.200900533

Improving mechanical properties of crystalline solids by cocrystal formation: new compressible forms of paracetamol

Shyam Karki
, Tomislav Friščić
, László Fabián
, Peter R. Laity
, Graeme M. Day
, William Jones^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

Original language	English
Pages (from-to)	3905-3909
Number of pages	5
Journal	Advanced Materials
Volume	21
Issue number	38-39
DOIs	https://doi.org/10.1002/adma.200900533
Publication status	Published - 19 Oct 2009

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.200900533

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title = "Improving mechanical properties of crystalline solids by cocrystal formation: new compressible forms of paracetamol",

abstract = "Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.",

author = "Shyam Karki and Tomislav Fri{\v s}{\v c}i{\'c} and L{\'a}szl{\'o} Fabi{\'a}n and Laity, \{Peter R.\} and Day, \{Graeme M.\} and William Jones",

year = "2009",

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T2 - new compressible forms of paracetamol

AU - Karki, Shyam

AU - Friščić, Tomislav

AU - Fabián, László

AU - Laity, Peter R.

AU - Day, Graeme M.

AU - Jones, William

PY - 2009/10/19

Y1 - 2009/10/19

N2 - Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

AB - Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

UR - https://www.scopus.com/pages/publications/70350342771

U2 - 10.1002/adma.200900533

DO - 10.1002/adma.200900533

M3 - Article

AN - SCOPUS:70350342771

SN - 0935-9648

VL - 21

SP - 3905

EP - 3909

JO - Advanced Materials

JF - Advanced Materials

IS - 38-39

ER -

Improving mechanical properties of crystalline solids by cocrystal formation: new compressible forms of paracetamol

Abstract

ASJC Scopus subject areas

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