Improving management of diabetic kidney disease: will GLP-1 receptor agonists have a role?

Srikanth Bellary, Abd Tahrani, Anthony H. Barnett

Research output: Contribution to journalComment/debatepeer-review

2 Citations (Scopus)
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Abstract

Kidney disease affects around 40% of people with type 2 diabetes and is a leading cause of morbidity and mortality. 1 Management of diabetic kidney disease has traditionally focused on tight glycaemic control (in the early stages) and blood pressure control (with agents that inhibit the renin–angiotensin system). 1 Despite this, most patients with diabetic kidney disease experience a gradual decline in kidney function, eventually progressing to end-stage kidney disease and an increased risk of cardiovascular events and mortality. Glucagon-like peptide-1 (GLP-1) receptor agonists are established treatments for type 2 diabetes that, in addition to lowering glucose, are associated with weight loss, lowering of blood pressure, and cardioprotection. 2 There is a lack of clarity, however, on the long-term benefits of GLP-1 receptor agonist therapy in patients with diabetic kidney disease, particularly in relation to glomerular function.
Original languageEnglish
JournalThe Lancet Diabetes and Endocrinology
DOIs
Publication statusPublished - 21 Sep 2020

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