Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature

Patricia Gorecki; Philipp Stockmann; Jörg H.w. Distler; Wolfgang Wuest; Daniela Schmidt; Friedrich Wilhelm Neukam; Emeka Nkenke; Falk Wehrhan

doi:10.1016/j.jmhi.2015.04.002

Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature

Patricia Gorecki, Philipp Stockmann, Jörg H.w. Distler, Wolfgang Wuest, Daniela Schmidt, Friedrich Wilhelm Neukam, Emeka Nkenke, Falk Wehrhan

Dentistry

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

519 Downloads (Pure)

Abstract

Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.

Original language	English
Pages (from-to)	72-78
Number of pages	7
Journal	Journal of Medical Hypotheses and Ideas
Volume	9
Issue number	2
Early online date	25 Apr 2015
DOIs	https://doi.org/10.1016/j.jmhi.2015.04.002
Publication status	Published - 1 Dec 2015

Access to Document

10.1016/j.jmhi.2015.04.002

Gorecki_et_al_Implication_bisphosphonate_use_Journal_Medical_Hypotheses_and_Ideas_2015
Published under a Creative Commons Non-Commercial No Derivatives license: http://creativecommons.org/licenses/by-nc-nd/4.0/. Eligibility for repository checked June 2015
Final published version, 1.12 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

http://linkinghub.elsevier.com/retrieve/pii/S2251729415000105

Cite this

@article{e6f24a2b76ce4d9fbd10bfb224f1cffd,

title = "Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature",

abstract = "Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.",

author = "Patricia Gorecki and Philipp Stockmann and Distler, {J{\"o}rg H.w.} and Wolfgang Wuest and Daniela Schmidt and Neukam, {Friedrich Wilhelm} and Emeka Nkenke and Falk Wehrhan",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.jmhi.2015.04.002",

language = "English",

volume = "9",

pages = "72--78",

journal = "Journal of Medical Hypotheses and Ideas",

issn = "2251-7294",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature

AU - Gorecki, Patricia

AU - Stockmann, Philipp

AU - Distler, Jörg H.w.

AU - Wuest, Wolfgang

AU - Schmidt, Daniela

AU - Neukam, Friedrich Wilhelm

AU - Nkenke, Emeka

AU - Wehrhan, Falk

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.

AB - Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.

U2 - 10.1016/j.jmhi.2015.04.002

DO - 10.1016/j.jmhi.2015.04.002

M3 - Article

SN - 2251-7294

VL - 9

SP - 72

EP - 78

JO - Journal of Medical Hypotheses and Ideas

JF - Journal of Medical Hypotheses and Ideas

IS - 2

ER -

Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature

Abstract

Access to Document

Fingerprint

Cite this