Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

Kareen Heinze; Helen C Barron; Emma K Howes; Mani Ramaswami; Matthew R Broome

doi:10.1192/bjp.2020.163

Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

Kareen Heinze, Helen C Barron, Emma K Howes, Mani Ramaswami, Matthew R Broome

Research output: Contribution to journal › Article › peer-review

Abstract

In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	British Journal of Psychiatry
DOIs	https://doi.org/10.1192/bjp.2020.163
Publication status	E-pub ahead of print - 23 Oct 2020

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10.1192/bjp.2020.163

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title = "Impaired inhibitory processing: a new therapeutic target for autism and psychosis?",

abstract = "In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.",

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AB - In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.

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JO - British Journal of Psychiatry

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Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

Abstract

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