Impaired energetics in heart failure - A new therapeutic target

Julian Ormerod, H Ashrafian, Michael Frenneaux

Research output: Contribution to journalReview article

10 Citations (Scopus)


Heart failure is a syndrome of huge and growing importance worldwide. It is widely accepted that the energy status of the myocardium in heart failure is impaired, irrespective of etiology. Agents which modify cardiac substrate utilisation have the potential to ameliorate this energy deficiency by increasing cardiac mechanical efficiency. This may represent a new therapeutic paradigm in heart failure. In this review we discuss existing and new agents that alter cardiac substrate use and summarise the data on clinical efficacy. (C) 2008 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)264-274
Number of pages11
JournalPharmacology & Therapeutics
Issue number3
Publication statusPublished - 1 Sept 2008


  • metabolic agents
  • heart failure
  • myocardial energetics


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