Impact of the APOE promoter polymorphisms on Aß deposition in Alzheimer's disease

Jean-Charles Lambert; DMA Mann; L Goumidi; Judith Harris; P Amouyel; T Iwatsubo; Corinne Lendon; M-C Chartier-Harlin

doi:10.1016/S0140-6736(00)04063-0

Impact of the APOE promoter polymorphisms on Aß deposition in Alzheimer's disease

Jean-Charles Lambert
, DMA Mann
, L Goumidi
, Judith Harris
, P Amouyel
, T Iwatsubo
, Corinne Lendon
, M-C Chartier-Harlin

Research output: Contribution to journal › Article

37 Citations (Scopus)

Abstract

Polymorphisms in the promoter region of the apolipoprotein E gene (APOE) affect the amount of amyloid peptide (A beta) in the brains of patients with Alzheimer's disease. We measured A beta load immunohistochemically in regions 8 and 9 of Brodman's area in 74 people with Alzheimer's disease. The amount of A beta deposition was independent of APOE genotype in our cohort. These findings in patients with confirmed Alzheimer's disease are consistent with the hypothesis that variation it; AWE expression directly affects Alzheimer's disease pathology.

Original language	English
Pages (from-to)	608-609
Number of pages	2
Journal	Lancet
Volume	357
DOIs	https://doi.org/10.1016/S0140-6736(00)04063-0
Publication status	Published - 1 Jan 2001

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abstract = "Polymorphisms in the promoter region of the apolipoprotein E gene (APOE) affect the amount of amyloid peptide (A beta) in the brains of patients with Alzheimer's disease. We measured A beta load immunohistochemically in regions 8 and 9 of Brodman's area in 74 people with Alzheimer's disease. The amount of A beta deposition was independent of APOE genotype in our cohort. These findings in patients with confirmed Alzheimer's disease are consistent with the hypothesis that variation it; AWE expression directly affects Alzheimer's disease pathology.",

author = "Jean-Charles Lambert and DMA Mann and L Goumidi and Judith Harris and P Amouyel and T Iwatsubo and Corinne Lendon and M-C Chartier-Harlin",

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T1 - Impact of the APOE promoter polymorphisms on Aß deposition in Alzheimer's disease

AU - Lambert, Jean-Charles

AU - Mann, DMA

AU - Goumidi, L

AU - Harris, Judith

AU - Amouyel, P

AU - Iwatsubo, T

AU - Lendon, Corinne

AU - Chartier-Harlin, M-C

PY - 2001/1/1

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N2 - Polymorphisms in the promoter region of the apolipoprotein E gene (APOE) affect the amount of amyloid peptide (A beta) in the brains of patients with Alzheimer's disease. We measured A beta load immunohistochemically in regions 8 and 9 of Brodman's area in 74 people with Alzheimer's disease. The amount of A beta deposition was independent of APOE genotype in our cohort. These findings in patients with confirmed Alzheimer's disease are consistent with the hypothesis that variation it; AWE expression directly affects Alzheimer's disease pathology.

AB - Polymorphisms in the promoter region of the apolipoprotein E gene (APOE) affect the amount of amyloid peptide (A beta) in the brains of patients with Alzheimer's disease. We measured A beta load immunohistochemically in regions 8 and 9 of Brodman's area in 74 people with Alzheimer's disease. The amount of A beta deposition was independent of APOE genotype in our cohort. These findings in patients with confirmed Alzheimer's disease are consistent with the hypothesis that variation it; AWE expression directly affects Alzheimer's disease pathology.

UR - https://www.scopus.com/pages/publications/0035941738

U2 - 10.1016/S0140-6736(00)04063-0

DO - 10.1016/S0140-6736(00)04063-0

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C2 - 11558492

VL - 357

SP - 608

EP - 609

JO - Lancet

JF - Lancet

ER -

Impact of the APOE promoter polymorphisms on Aß deposition in Alzheimer's disease

Abstract

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