TY - JOUR
T1 - Impact of the APOE promoter polymorphisms on Aß deposition in Alzheimer's disease
AU - Lambert, Jean-Charles
AU - Mann, DMA
AU - Goumidi, L
AU - Harris, Judith
AU - Amouyel, P
AU - Iwatsubo, T
AU - Lendon, Corinne
AU - Chartier-Harlin, M-C
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Polymorphisms in the promoter region of the apolipoprotein E gene (APOE) affect the amount of amyloid peptide (A beta) in the brains of patients with Alzheimer's disease. We measured A beta load immunohistochemically in regions 8 and 9 of Brodman's area in 74 people with Alzheimer's disease. The amount of A beta deposition was independent of APOE genotype in our cohort. These findings in patients with confirmed Alzheimer's disease are consistent with the hypothesis that variation it; AWE expression directly affects Alzheimer's disease pathology.
AB - Polymorphisms in the promoter region of the apolipoprotein E gene (APOE) affect the amount of amyloid peptide (A beta) in the brains of patients with Alzheimer's disease. We measured A beta load immunohistochemically in regions 8 and 9 of Brodman's area in 74 people with Alzheimer's disease. The amount of A beta deposition was independent of APOE genotype in our cohort. These findings in patients with confirmed Alzheimer's disease are consistent with the hypothesis that variation it; AWE expression directly affects Alzheimer's disease pathology.
UR - http://www.scopus.com/inward/record.url?scp=0035941738&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(00)04063-0
DO - 10.1016/S0140-6736(00)04063-0
M3 - Article
C2 - 11558492
SN - 1474-547X
VL - 357
SP - 608
EP - 609
JO - Lancet
JF - Lancet
ER -