Immunomodulation by vitamin D: implications for TB

Rene F Chun, John S Adams, Martin Hewison

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

TB remains a major cause of mortality throughout the world. Low vitamin D status has been linked to increased risk of TB and other immune disorders. These observations suggest a role for vitamin D as a modulator of normal human immune function. This article will detail the cellular and molecular mechanisms by which vitamin D regulates the immune system and how vitamin D insufficiency may lead to immune dysregulation. The importance of vitamin D bioavailability as a mechanism for defining the immunomodulatory actions of vitamin D and its impact on TB will also be discussed. The overall aim will be to provide a fresh perspective on the potential benefits of vitamin D supplementation in the prevention and treatment of TB.

Original languageEnglish
Pages (from-to)583-91
Number of pages9
JournalExpert Review of Clinical Pharmacology
Volume4
Issue number5
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Adaptive Immunity
  • Animals
  • Clinical Trials as Topic
  • Humans
  • Immunologic Factors
  • Immunomodulation
  • Tuberculosis, Pulmonary
  • Vitamin D

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