Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Daniel F J Ketelhuth; Esther Lutgens; Magnus Bäck; Christoph J Binder; Jan Van den Bossche; Carolin Daniel; Ingrid Dumitriu; Imo Hoefer; Peter Libby; Luke O'Neill; Christian Weber; Paul C Evans

doi:10.1093/cvr/cvz166

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Daniel F J Ketelhuth
, Esther Lutgens
, Magnus Bäck
, Christoph J Binder
, Jan Van den Bossche
, Carolin Daniel
, Ingrid Dumitriu
, Imo Hoefer
, Peter Libby
, Luke O'Neill
, Christian Weber
, Paul C Evans

Cardiovascular Sciences

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.

Original language	English
Pages (from-to)	1385-1392
Number of pages	8
Journal	Cardiovascular Research
Volume	115
Issue number	9
DOIs	https://doi.org/10.1093/cvr/cvz166
Publication status	Published - 1 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Arteries/immunology
Atherosclerosis/immunology
Consensus
Energy Metabolism/immunology
Humans
Immune System/immunology
Immunomodulation
Inflammation/immunology
Inflammation Mediators/immunology
Macrophages/immunology
Monocytes/immunology
Plaque, Atherosclerotic
Signal Transduction
T-Lymphocytes/immunology

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10.1093/cvr/cvz166

Cite this

Ketelhuth, D. F. J., Lutgens, E., Bäck, M., Binder, C. J., Van den Bossche, J., Daniel, C., Dumitriu, I., Hoefer, I., Libby, P., O'Neill, L., Weber, C., & Evans, P. C. (2019). Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovascular Research, 115(9), 1385-1392. https://doi.org/10.1093/cvr/cvz166

@article{80d3e78f69ef48bebdde43ec39abac75,

title = "Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology",

abstract = "Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.",

keywords = "Animals, Arteries/immunology, Atherosclerosis/immunology, Consensus, Energy Metabolism/immunology, Humans, Immune System/immunology, Immunomodulation, Inflammation/immunology, Inflammation Mediators/immunology, Macrophages/immunology, Monocytes/immunology, Plaque, Atherosclerotic, Signal Transduction, T-Lymphocytes/immunology",

author = "Ketelhuth, \{Daniel F J\} and Esther Lutgens and Magnus B{\"a}ck and Binder, \{Christoph J\} and \{Van den Bossche\}, Jan and Carolin Daniel and Ingrid Dumitriu and Imo Hoefer and Peter Libby and Luke O'Neill and Christian Weber and Evans, \{Paul C\}",

year = "2019",

month = jul,

day = "1",

doi = "10.1093/cvr/cvz166",

language = "English",

volume = "115",

pages = "1385--1392",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

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}

Ketelhuth, DFJ, Lutgens, E, Bäck, M, Binder, CJ, Van den Bossche, J, Daniel, C, Dumitriu, I, Hoefer, I, Libby, P, O'Neill, L, Weber, C & Evans, PC 2019, 'Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology', Cardiovascular Research, vol. 115, no. 9, pp. 1385-1392. https://doi.org/10.1093/cvr/cvz166

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. / Ketelhuth, Daniel F J; Lutgens, Esther; Bäck, Magnus et al.
In: Cardiovascular Research, Vol. 115, No. 9, 01.07.2019, p. 1385-1392.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Immunometabolism and atherosclerosis

T2 - perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

AU - Ketelhuth, Daniel F J

AU - Lutgens, Esther

AU - Bäck, Magnus

AU - Binder, Christoph J

AU - Van den Bossche, Jan

AU - Daniel, Carolin

AU - Dumitriu, Ingrid

AU - Hoefer, Imo

AU - Libby, Peter

AU - O'Neill, Luke

AU - Weber, Christian

AU - Evans, Paul C

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.

AB - Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.

KW - Animals

KW - Arteries/immunology

KW - Atherosclerosis/immunology

KW - Consensus

KW - Energy Metabolism/immunology

KW - Humans

KW - Immune System/immunology

KW - Immunomodulation

KW - Inflammation/immunology

KW - Inflammation Mediators/immunology

KW - Macrophages/immunology

KW - Monocytes/immunology

KW - Plaque, Atherosclerotic

KW - Signal Transduction

KW - T-Lymphocytes/immunology

U2 - 10.1093/cvr/cvz166

DO - 10.1093/cvr/cvz166

M3 - Review article

C2 - 31228191

SN - 0008-6363

VL - 115

SP - 1385

EP - 1392

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 9

ER -

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Abstract

UN SDGs

Keywords

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