Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells

Kathryn J Wood, Andrew Bushell, Nick D Jones

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Exposure to alloantigen in vivo or in vitro induces alloantigen reactive regulatory T cells that can control transplant rejection. The mechanisms that underpin the activity of alloantigen reactive regulatory T cells in vivo are common with those of regulatory T cells that prevent autoimmunity. The identification and characterization of regulatory T cells that control rejection and contribute to the induction of immunologic unresponsiveness to alloantigens in vivo has opened up exciting opportunities for new therapies in transplantation. Findings from laboratory studies are informing the design of clinical protocols using regulatory T cells as a cellular therapy.
Original languageEnglish
Pages (from-to)119-32
Number of pages14
JournalImmunological Reviews
Volume241
Issue number1
DOIs
Publication statusPublished - May 2011

Keywords

  • Animals
  • T-Lymphocytes, Regulatory
  • Isoantigens
  • Graft Rejection
  • Humans
  • Immunotherapy, Adoptive
  • Autoimmunity
  • Immune Tolerance
  • Organ Transplantation
  • Clinical Protocols

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